Treatment of Wegener’s Granulomatosis
Treatment and outcome of 111 patients who fell ill with Wegener’s granulomatosis (WG) between 1966 and 1990 were analysed retrospectively. Two regimens of treatment were distinguished: “conventional” treatment, i.e. daily application of cyclophosphamide/corticosteroids (FAUCI scheme) or azathioprine/ corticosteroids or corticosteroids alone, and “stage-adapted” treatment, characterized by change of different treatments (e.g. cyclophosphamide pulse therapy, cotrimoxazole) according to the extent and activity of disease. In patients who received stage-adapted treatment, exacerbations occurred significantly more frequent than in conventionally treated patients, while lethal outcome was much more frequent in conventionally treated patients.
KeywordsComplete Remission Lupus Nephritis Partial Remission Renal Complication Lethal Outcome
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