Summary
43 patients with Wegener’s granulomatosis were studied to evaluate the effectiveness of cyclophosphamide (cyc) pulse treatment. 42% of the patients showed benefits from treatment for at least 6 months after the cessation of cyc pulses. Analysis of clinical and laboratory parameters indicate that this treatment is less effective in patients in whom more than 4 organ systems are involved. Responders to the treatment showed disease manifestations predominantly in the ENT and lower respiratory tract and had lower cANCA titers ( < 1:64) prior to treatment.
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© 1993 Springer Science+Business Media New York
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Reinhold-Keller, E., Kekow, J., Schnabel, A., Schwarz-Eywill, M., Schmitt, W.H., Gross, W.L. (1993). Effectiveness of Cyclophosphamide Pulse Treatment in Wegener’s Granulomatosis. In: Gross, W.L. (eds) ANCA-Associated Vasculitides. Advances in Experimental Medicine and Biology, vol 336. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9182-2_87
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DOI: https://doi.org/10.1007/978-1-4757-9182-2_87
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