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Effectiveness of Cyclophosphamide Pulse Treatment in Wegener’s Granulomatosis

  • Eva Reinhold-Keller
  • Jörn Kekow
  • Armin Schnabel
  • Michael Schwarz-Eywill
  • Wilhelm H. Schmitt
  • Wolfgang L. Gross
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 336)

Summary

43 patients with Wegener’s granulomatosis were studied to evaluate the effectiveness of cyclophosphamide (cyc) pulse treatment. 42% of the patients showed benefits from treatment for at least 6 months after the cessation of cyc pulses. Analysis of clinical and laboratory parameters indicate that this treatment is less effective in patients in whom more than 4 organ systems are involved. Responders to the treatment showed disease manifestations predominantly in the ENT and lower respiratory tract and had lower cANCA titers ( < 1:64) prior to treatment.

Keywords

Lower Respiratory Tract Partial Remission Renal Involvement Organ Involvement Pulse Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. De Vita, S., Neri, R., and Bombardieri, S., 1991, Cyclophosphamide pulses in the treatment of rheumatic diseases: an update, Cin.Exp.Rheumatol 9: 179.Google Scholar
  2. Haubitz, M., Frei, U., Rother, U., Brunkhorst, R., and Koch, K.M., 1991, Cyclophosphamide pulse therapy in Wegener’s granulomatosis, NephrolDial Transplant. 6: 531.Google Scholar
  3. Hoffman, G.S., Kerr, G.S., Leavitt, R.Y., Hallahan, C.W., Lebovics, R.S., Travis, W.D., Rottem, M., and Fauci, A.S., 1992, Wegener granulomatosis: An analysis of 158 patients, Ann.Intern.Med. 116: 488.PubMedCrossRefGoogle Scholar
  4. Hoffman, G.S., Leavitt, R.Y., Fleisher, T.A., Minor, J.R., and Fauci, A.S., 1990, Treatment of Wegener’s granulomatosis with intermittent high-dose intravenous cyclophosphamide, Am.J.Med. 89: 403.PubMedCrossRefGoogle Scholar
  5. Schmitt, W.H., Heesen, C., Csernok, E., Rautmann, A., and Gross, W.L., 1992, Elevated serum levels of soluble interleukin-2 receptor (sIL-2R) in Wegener’s granulomatosis (WG): Association with disease activity, Arthritis Rheum. 35: 1088.PubMedCrossRefGoogle Scholar
  6. Steppat, D. and Gross, W.L., 1989, Stage-adapted treatment of Wegener’s granulomatosis, Klin. Wochenschr. 67: 666.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Eva Reinhold-Keller
    • 1
    • 2
  • Jörn Kekow
    • 1
    • 2
  • Armin Schnabel
    • 1
    • 2
  • Michael Schwarz-Eywill
    • 1
    • 2
  • Wilhelm H. Schmitt
    • 1
    • 2
  • Wolfgang L. Gross
    • 1
    • 2
  1. 1.Department of Clinical RheumatologyMedical University at LübeckBad BramstedtGermany
  2. 2.Department of MedicineRheumaklinik Bad Bramstedt GmbHBad BramstedtGermany

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