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Cyclosporin a Therapy for Wegener’s Granulomatosis

  • Nancy B. Allen
  • David S. Caldwell
  • John R. Rice
  • Rex M. McCallum
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 336)

Summary

Five patients with active Wegener’s granulomatosis were treated with the immunosuppressive agent Cyclosporin A, along with low dose prednisone. All five patients had previously taken cyclophosphamide, but further treatment with this agent was not desired, either due to patient choice, drug toxicity or malignancy. In initial doses of up to 5mg/kg/day, CyA showed efficacy but when lowered to 1–2mg/kg/day, mild disease flares occurred. CyA may provide an alternative to traditional therapy in selected patients with WG.

Keywords

Hemorrhagic Cystitis Traditional Therapy Ocular Inflammatory Disease Pulse Intravenous Cyclophosphamide Clinicopathologic Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Nancy B. Allen
    • 1
  • David S. Caldwell
    • 1
  • John R. Rice
    • 1
  • Rex M. McCallum
    • 1
  1. 1.Division of Rheumatology and Immunology Department of MedicineDuke University Medical CenterDurhamUSA

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