Indentification of Apparent Dual ANCA Specificities in a Subset of Patients with Systemic Vasculitis and Crescentic Glomerulonephritis
23% of a random selection of ANCA (+) patients had dual, non-cross reactive autoantibody specificities. We found no clinical difference in such patients as compared to those having a single antibody. A second group of ANCA (+) patients had neither anti-MPO nor anti-PR3 autoantibody specificity. These findings suggest that multiple, coincident ANCA specificities occur more commonly than previously reported, and that additional, unidentified ANCA specificities are present in some patients.
KeywordsFormalin Vasculitis Azide Nephritis Cholangitis
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