Indentification of Apparent Dual ANCA Specificities in a Subset of Patients with Systemic Vasculitis and Crescentic Glomerulonephritis
23% of a random selection of ANCA (+) patients had dual, non-cross reactive autoantibody specificities. We found no clinical difference in such patients as compared to those having a single antibody. A second group of ANCA (+) patients had neither anti-MPO nor anti-PR3 autoantibody specificity. These findings suggest that multiple, coincident ANCA specificities occur more commonly than previously reported, and that additional, unidentified ANCA specificities are present in some patients.
KeywordsUlcerative Colitis Primary Sclerosing Cholangitis Crescentic Glomerulonephritis Autoantibody Specificity Alkaline Phosphatase Substrate
Unable to display preview. Download preview PDF.
- Cohen Tervaert, J.W., Goldschmeding, R., Elema, J.D., Van der Giessen, M., Huitema, M.G., Van der Hem, G.K., The, T.H., von dem Borne, A.E.G.Kr., and Kallenberg, C.G.M., 1990, Autoantibodies against myeloid lysosomal enzymes in crescentic glomerulonephritis, Kidney Int. 37: 799–806.CrossRefGoogle Scholar
- Goldschmeding, R., van der Schoot, C.E., Cohen Tervaert, J.W., Mason, D.Y., von dem Borne, A.E.G.Kr., and Kallenberg, C.G.M., 1988, Autoantibodies against myeloid lysosomal enzymes: a novel class of autoantibodies associated with vasculitic syndromes, Kidneylnt. 34: 588.Google Scholar
- Hardarson, S., LaBreque, D.R., Mitros,F.A., Neil, G., Goeken, J.A., 1991, Anti-neutrophil cytoplasmic antibody (ANCA) associated with ulcerative colitis and primary sclerosing cholangitis, Gastroenterology 100: A609.Google Scholar