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P-ANCA with Myeloperoxidase Antibodies and C-ANCA with Proteinase 3 Antibodies Define a Different Vasculitis Entity in Patients with Renal Involvement

  • C. Dringenberg
  • S. Apenberg
  • K. Andrassy
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 336)

Summary

In a 3 year period 359/3685 patients with suspected vasculitis had a positive ANCA-IF. C-ANCA were found in 146/359 and p-ANCA in 213/359 patients. PANCA and MPO-antibodies were more frequently associated with female gender and preglomerular vasculitis, whereas c-ANCA (WG) were more frequent in males without renal vasculitis.

Detection of anti-neutrophil cytoplasmic antibodies (ANCA) has facilitated the diagnosis of Wegener’s granulomatosis (WG) and microscopic polyarteritis (MP), important representatives of small vessel vasculitides (SVV). C-ANCA with proteinase 3 antibodies (PR 3-AB) are typical of WG and p-ANCA with myeloperoxidase antibodies (MPO-AB) are typical of MP in our country. We reported recently (1) about an association between crescentic glomerulonephritis, renal vasculitis, p-ANCA, myeloperoxidase-AB and female gender in a small cohort of patients with rapidly progressive glomerulonephritis (RPGN). In the following we analyzed whether in a larger cohort of patients with SVV this preliminary statements could be confirmed.

Keywords

Female Gender Renal Involvement Crescentic Glomerulonephritis Collagen Vascular Disease Small Vessel Vasculitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Rasmussen, N., Sjoelin, C., Isaksson, B., Bygren, P., Wieslander, J., 1990, An Elisa for the detection of antineutrophil cytoplasm antibodies, J.Irnmunol.Meth. 127: 139–145CrossRefGoogle Scholar
  2. 2.
    Andrassy, K., Koderisch, J., Schaefer, A., Waldherr, R.,1990, Idiopathic rapidly progressive crescentic glomerulonephritis with myeloperoxidase antibodies–a new entitiy linked to female sex? Nephron 56: 99–100PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • C. Dringenberg
    • 1
  • S. Apenberg
    • 1
  • K. Andrassy
    • 1
  1. 1.Dept. of MedicineUniversity of HeidelbergGermany

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