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ANCA and Anti-GBM Antibodies in RPGN

  • Andrew K. Short
  • Vincent L. M. Esnault
  • C. Martin Lockwood
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 336)

Summary

ANCA and anti-GBM antibodies can occur together in RPGN. These patients are rare and have two distinct populations of antibodies and the ANCA specificity tends to be for myeloperoxidase more often than expected.

Keywords

Unbind Fraction Cyanogen Bromide Rapidly Progressive Glomerulonephritis Basement Membrane Disease Cross Inhibition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Andrews PC and Krinsky NI., Human myeloperoxidase and hemi-peroxidase. Methods in Enzymology 132: (1986) 369–378PubMedCrossRefGoogle Scholar
  2. Bosch X et al., Prognostic implication of anti-neutrophil cytoplasmic autoantibodies with myeloperoxidase specificity in anti-glomerular basement membrane disease. Clinical Nephrology 36: 3; 107–113 (1991)PubMedGoogle Scholar
  3. Jayne DRW et al., Autoantibodies to glomerular basement membrane and neutrophil cytoplasm in rapidly progressive glomerulonephritis. Kidney International 37 (1990): 965–970PubMedCrossRefGoogle Scholar
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  5. Makker SP and Kanalas JJ., Renal antigens in mercuric chloride induced anti-GBM autoantibody glomerular diseases. Kidney International 37 (1990): 64–71PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Andrew K. Short
    • 1
  • Vincent L. M. Esnault
    • 2
  • C. Martin Lockwood
    • 1
  1. 1.Department of MedicineUniversity of CambridgeCambridgeUK
  2. 2.Service de Nephrologie-immunologie cliniqueCHRUNantesFrance

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