Rapidly Progressive Glomerulonephritis (RPGN): Is there Still an “Idiopathic” Subgroup?
In order to clarify if “idiopathic” RPGN still exists as a distinct entity we reviewed 41 patients with histological picture of diffuse crescentic GN (60% of crescents) and no clinical evidence of systemic disease. According to the presence or absence of intraglomerular necrotizing lesions we subdivided the patients into two different morphological groups: Group I (25 pts) with necrotizing GN and massive periglomerular infiltrates; Group II (16 pts) with intra-extracapillary proliferation and no interstitial infiltrates. Our data suggest that “idiopathic” RPGN does not exist as a distinct entity, but is an expression either of renal limited vasculitis or crescentic GN complicating primary proliferative GN.
KeywordsSystemic Vasculitis Crescentic Glomerulonephritis Histological Picture Mesangial Proliferation Rapidly Progressive Glomerulonephritis
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- 1.Couser W.G. 1988. Rapidly progressive glomerulonephritis: classification, pathogenetic mechanism and therapy. Am J Kidney Dis 6: 449–464.Google Scholar
- 4.Stiluran M.M., Bolton W.K., Sturgill B.C., Schmitt G.W., Couser W.G. 1979. Crescentic glomerulonephritis without immune deposits: clinico-pathologic features. Kidney Int 15: 184195.Google Scholar