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Rapidly Progressive Glomerulonephritis (RPGN): Is there Still an “Idiopathic” Subgroup?

  • F. Ferrario
  • M. Tadros
  • P. Napodano
  • A. Giordano
  • R. A. Sinico
  • G. Fellin
  • G. D’Amico
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 336)

Summary

In order to clarify if “idiopathic” RPGN still exists as a distinct entity we reviewed 41 patients with histological picture of diffuse crescentic GN (60% of crescents) and no clinical evidence of systemic disease. According to the presence or absence of intraglomerular necrotizing lesions we subdivided the patients into two different morphological groups: Group I (25 pts) with necrotizing GN and massive periglomerular infiltrates; Group II (16 pts) with intra-extracapillary proliferation and no interstitial infiltrates. Our data suggest that “idiopathic” RPGN does not exist as a distinct entity, but is an expression either of renal limited vasculitis or crescentic GN complicating primary proliferative GN.

Keywords

Systemic Vasculitis Crescentic Glomerulonephritis Histological Picture Mesangial Proliferation Rapidly Progressive Glomerulonephritis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • F. Ferrario
    • 1
  • M. Tadros
    • 1
  • P. Napodano
    • 1
  • A. Giordano
    • 1
  • R. A. Sinico
    • 1
  • G. Fellin
    • 1
  • G. D’Amico
    • 1
  1. 1.Division of NephrologySan Carlo HospitalMilanoItaly

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