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Presence of Anticardiolipin Antibodies Discriminates Between Wegener’s Granulomatosis and Microscopic Polyarteritis

  • O. Hergesell
  • R. Egbring
  • K. Andrassy
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 336)

Summary

ANCA-tests are not always useful in evaluation of disease activity of patients with Wegener’s granulomatosis (WG) and microscopic polyarteritis(MP). If ANCAtests are failing in patients with Wegener’s granulomatosis or microscopic polyarteritis, markers of activated coagulation are helpful in evaluation of disease activity. The measurement of anticardiolipin antibodies(ACA) may allow to discriminate between MP and WG, since ACA are only significantly elevated in patients with MP.

Anticardiolipin antibodies (ACA) are acquired autoantibodies that are found in patients with a wide spectrum of clinical conditions, mainly systemic lupus erythematosus and related disorders. They are associated with increased thrombotic tendency (1). We investigated in patients with ANCA-positive vasculitis whether membrane phospholipids exposed in injured endothelial cells might stimulate the formation of ACA, thus contributing to the vascular thrombotic occlusion besides the activation of coagulation (2).

Keywords

Systemic Lupus Erythematosus Giant Cell Arteritis Lupus Anticoagulant Anticardiolipin Antibody Rapidly Progressive Glomerulonephritis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    Hergesell, O., Andrassy, K., Schaefer, A., Zeier, M.,1991, Activation of haemostasis (TAT, F1+2, DDimers) as monitor of disease activity in patients with systemic necrotizing vasculitis (abstract), JASN 2: 596Google Scholar
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • O. Hergesell
    • 1
  • R. Egbring
    • 1
  • K. Andrassy
    • 1
  1. 1.Departments of MedicineUniversity of Heidelberg and MarburgGermany

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