Skip to main content

Polyarteritis Nodosa and Churg-Strauss Syndrome an Internist’s View

  • Chapter
ANCA-Associated Vasculitides

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 336))

Abstract

Vasculitides of the polyarteritis nodosa group and Wegener’s granulomatosis are rare diseases and determination of the optimal diagnostic investigations and treatment is difficult. Over the past decade, we have observed and treated 143 vasculitis patients in our Department of Internal Medicine and have also carried out several prospective trials 1,2,3 which have included 300 patients. Our presentation is based on these results.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 259.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. L. Guillevin, B. Jarrousse, C. Lok, F. Lhote, Ph. Jais, T.D.H. Le, and A. Bussel. Long-term follow-up after treatment of polyarteritis nodosa and Churg-Strauss angiitis with comparison of steroids, plasma exchange and cyclophosphamide to steroids and plasma exchange. A prospective randomized trial of 71 patients J. Rheumatol., 18: 576–584, 1991

    Google Scholar 

  2. L. Guillevin, O. Fain, F. Lhote, B. Jarrousse, L.T.H. Du, A. Bussel and A. Leon A lack of superiority of steroid plus plasma exchange to steroids alone in the treatment of polyarteritis nodosa and Churg Strauss syndrome Arthritis Rheum., 35: 208–214, 1992

    CAS  Google Scholar 

  3. L. Guillevin, F. Lhote, A. Leon, F. Fauvelle, L. Vivitski, C. Trepo Treatment of polyarteritis nodosa related to hepatitis B virus with short-term steroid therapy associated with antiviral agents and plasma exchanges. a prospective trial in 33 patients. J. Rheumatol. 1993 (in press)

    Google Scholar 

  4. R.W. Jr Lightfoot, B.A. Michel, D.A. Bloch, G.G. Hunder, N.J. Zvaifler, D.J. McShane, W.P. Arend, L.H. Calabrese, R.Y. Leavitt, T.J. Lie, A.T. Masi, J.A. Mills, M.B. Stevens, S.L Wallace The American College of Rheumatology 1990: criteria for the classification of polyarteritis nodosa Arthritis Rheum., 33: 1088–1093, 1990

    Google Scholar 

  5. A.T. Masi, G.G. Hunder, J.T. Lie and al The American College of Rheumatology 1990: criteria for the classification of Churg-Strauss syndrome (allergic granulomatosis and angiitis) Arthritis Rheum., 33: 1094–1100, 1990

    CAS  Google Scholar 

  6. P.P. Frohnert, S.G. S.eps Long-term follow-up study of periarteritis nodosa Am. J. Med., 43: 8–14, 1967

    CAS  Google Scholar 

  7. E.S. Leib, C. Restivo and H.E. Paulus Immunosuppressive and corticosteroid therapy of polyarteritis nodosa Am. J. Med., 67: 941–947, 1979

    Article  CAS  Google Scholar 

  8. A.S Fauci, P. Katz and B.F. Haynes, S. M. Wolff Cyclophosphamide therapy of severe necrotizing vasculitis N. Engl. J. Med., 301: 3235–238, 1979

    Google Scholar 

  9. R.D. Cohen, D.L. Conn, D.M.Ilstrup Clinical features, prognosis, and response to treatment of polyarteritis Mayo Clin. Proc., 55: 146–155, 1980

    CAS  Google Scholar 

  10. L. Guillevin, T.H.D. Le, P. Godeau, J. Ph. Jais, B. Wechler Clinical findings and prognosis of polyarteritis nodosa and Churg Strauss Angiitis: a study in 165 patients Brit. J. Rheumatol., 27: 258–264, 1988

    Article  CAS  Google Scholar 

  11. O. Bletry, A. Bussel, I. Badelon, L. Guillevin, P. Lesavre, S. Herson, P. Godeau Interêt des échanges plasmatiques au cours des angeites nécrosantes. Onze cas Nouv Presse Med., 11: 2827–2832, 1982

    CAS  Google Scholar 

  12. C.M. Lockwood, S. Worledge, A. Nicholas, C. Cotton, D. K. Peters Reversal of impaired splenic function in patients with nephritis or vasculitis (or both) by plasma exchange N. Engl. J. Med., 300: 524–530, 1979

    Article  PubMed  CAS  Google Scholar 

  13. J.M. Chalopin, G. Rifle, J.M. Turc, P. Cortet, M. Severac Immunological findings during successful treatment of Hbs Ag-associated polyarteritis nodosa by plasmapheresis alone Brit. M.d. J., 1980, 1, 368

    Google Scholar 

  14. L. Guillevin, Y. Tanter, O. Bletry, J. M. Chalopin, C. Lok, G. Andreu, G. Rifle, P. Godeau Treatment of severe polyarteritis nodosa with plasma exchange Prog Artif Organs, edited by K Atsumi, M Maekawa, K Ota, Cleveland, ISAO Press, 723–726, 1983

    Google Scholar 

  15. R. Peto, M.C. Pike, P. Armitage Design and analysis of randomized clinical trials requiring prolonged observations of each patient. II. Analysis and examples. Brit. J. Cancer, 35: 1–19, 1977

    Article  CAS  Google Scholar 

  16. Cox DR Regression models and life tables J. R. Stat. Soc., 34: 187–219, 1972

    Google Scholar 

  17. C.O.C. Savage, C.G. Winearls, S. Jones and al. Prospective study of radioimmunoassay for antibodies against neutrophil cytoplasm in diagnosis of systemic vasculitis Lancet, 1: 1389–1393, 1987

    Article  PubMed  CAS  Google Scholar 

  18. J.W. Cohen-Tervaert, M.G. Huitema Prevention of relapses in Wegener’s granulomatosis by treatment based on antineutrophil cytoplasmic antibody titre Lancet, 2: 709–711, 1990

    Article  Google Scholar 

  19. R.J. Falk, J.C. Jennette Antineutrophil cytoplasmic antibodies with specificity for myeloperoxydase in patients with systemic vasculitis and idiopathic and crescentic glomerulonephritis. N Engl J Med, 318: 1651–1657, 1988

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer Science+Business Media New York

About this chapter

Cite this chapter

Guillevin, L., Gayraud, M., Casassus, P. (1993). Polyarteritis Nodosa and Churg-Strauss Syndrome an Internist’s View. In: Gross, W.L. (eds) ANCA-Associated Vasculitides. Advances in Experimental Medicine and Biology, vol 336. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9182-2_28

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-9182-2_28

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9184-6

  • Online ISBN: 978-1-4757-9182-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics