Further Characterization of an Animal Model of Systemic Vasculitis
The demonstration of vasculitis and anti-myeloperoxidase antibodies in the mercuric chloride treated Brown Norway rat provides a useful, though limited, animal model of systemic vasculitis. We describe some preliminary experiments on the effect of transfer of serum from mercuric chloride treated rats and of two forms of immunotherapy: intravenous immunoglobulin and an anti-CD4 antibody. Transfer of serum did not lead to tissue injury and neither of the two forms of therapy proved beneficial in this model.
KeywordsIntravenous Immunoglobulin Mercuric Chloride Systemic Vasculitis Brown Norway Necrotizing Vasculitis
Unable to display preview. Download preview PDF.
- 2.Pelletier L., Pasquier R., Hirsch F., Sapin C., Druet P.,1986, Autoreactive T cells in mercury-induced autoimmune disease: in vitro demonstration. J.Immunol. 137: 2548–2554.Google Scholar
- 3.Pelletier L., Pasquier R., Rossert J., Vial M-C., Druet P.,1988, Autoreactive T cells in mercury induced autoimmunity: ability to induce the autoimmune disease, J.Immuno1. 140: 750–754.Google Scholar