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Further Characterization of an Animal Model of Systemic Vasculitis

  • F. J. Qasim
  • P. W. Mathieson
  • S. Thiru
  • D. B. G. Oliveira
  • C. M. Lockwood
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 336)

Summary

The demonstration of vasculitis and anti-myeloperoxidase antibodies in the mercuric chloride treated Brown Norway rat provides a useful, though limited, animal model of systemic vasculitis. We describe some preliminary experiments on the effect of transfer of serum from mercuric chloride treated rats and of two forms of immunotherapy: intravenous immunoglobulin and an anti-CD4 antibody. Transfer of serum did not lead to tissue injury and neither of the two forms of therapy proved beneficial in this model.

Keywords

Intravenous Immunoglobulin Mercuric Chloride Systemic Vasculitis Brown Norway Necrotizing Vasculitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • F. J. Qasim
    • 1
  • P. W. Mathieson
    • 1
  • S. Thiru
    • 1
  • D. B. G. Oliveira
    • 1
  • C. M. Lockwood
    • 1
  1. 1.Departments of Medicine and PathologyUniversity of CambridgeCambridgeEngland

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