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Myeloperoxidase Binds to Vascular Endothelial Cells, is Recognized by ANCA and can Enhance Complement Dependent Cytotoxicity

  • Caroline O. S. Savage
  • Gillian Gaskin
  • Charles D. Pusey
  • Jeremy D. Pearson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 336)

Summary

Myeloperoxidase (MPO) and proteinase-3 (Pr-3) can bind to vascular endothelial cells (EC) and are available for recognition by autoantibodies present in P-ANCA or C-ANCA containing sera, respectively. The bound MPO also retains its enzymic functions and effectively interacts with hydrogen peroxide to mediate detachment of endothelial cells from their substratum. EC bound MPO-anti-MPO complexes can contribute to the complement-dependent EC injury demonstrated by some P-ANCA sera.

Keywords

Hypochlorous Acid Complement Dependent Cytotoxicity Alkaline Phosphatase Detection Microscopic Polyarteritis Control Endothelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Falk, R.J., Terrell, R.S., Charles, L.A. and Jennette, J.C., 1990, Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro, Proc Natl Acad Sci USA. 87: 4115–4119PubMedCrossRefGoogle Scholar
  2. Savage, C.O.S., Pottinger, B., Gaskin, G., Lockwood, C.M., Pusey, C.D. and Pearson, J., 1991, Vascular damage in Wegener’s granulomatosis and microscopic polyarteritis: presence of anti-endothelial cell antibodies and their relation to anti-neutrophil cytoplasm antibodies, Clin exp Immunol. 85: 14–19PubMedCrossRefGoogle Scholar
  3. Savage, C.O.S., Pottinger, B.E., Gaskin, G., Pusey, C.D. and Pearson, J.D., 1992, Autoantibodies developing to myeloperoxidase and proteinase 3 in systemic vasculitis stimulate neutrophil cytotoxicity towards cultured endothelial cells. Am J Pathol. 144: 335–342Google Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Caroline O. S. Savage
    • 1
    • 2
  • Gillian Gaskin
    • 2
  • Charles D. Pusey
    • 2
  • Jeremy D. Pearson
    • 1
  1. 1.Vascular Biology SectionClinical Research CentreHarrowUK
  2. 2.Department of Renal MedicineHammersmith HospitalLondonUK

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