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Pooled Human IgG (PHIG) Inhibits the Binding of Anti-Myeloperoxidase Antibodies to Myeloperoxidase

  • A. A. Pall
  • M. Varagunam
  • D. Adu
  • N. Smith
  • C. M. Taylor
  • J. Michael
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 336)

Summary

This study demonstrates that pooled human immunoglobulin (PHIG) contains anti-idiotypes to anti-myeloperoxidase (MPO) antibodies and can inhibit the binding of anti-MPO to MPO. The variability seen in the inhibitory effect of different PHIG preparations in the same and also in different patient sera suggests heterogeneity in the idiotypic repertoire of anti-MPO antibodies.

Keywords

Systemic Vasculitis Crescentic Glomerulonephritis Autoimmune Connective Tissue Disease Microscopic Polyarteritis Normal Human Immunoglobulin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • A. A. Pall
    • 1
  • M. Varagunam
    • 1
  • D. Adu
    • 1
  • N. Smith
    • 1
  • C. M. Taylor
    • 1
  • J. Michael
    • 1
  1. 1.Renal Research LaboratoriesQueen Elizabeth Hospital BirminghamEngland

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