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Cross-Reactivity between Antibodies to Thyroid Microsomal Antigens and Myeloperoxidase

  • A. M. Haapala
  • H. Hyöty
  • E. Soppi
  • P. Parkkonen
  • J. Mustonen
  • A. Pasternack
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 336)

Summary

Antibodies against thyroid microsomal antigen (thyroid peroxidase, TMA/TPO) and myeloperoxidase (MPO) were measured from 115 patients with vasculitic disorders and 144 patients with suspected thyroid disorders. Nineteen patients, three with vasculitis and 16 with thyroid disorders, were shown to have both TPO and MPO antibodies, suggesting cross-reactivity of these antibodies. Their cross-reactivity was further strengtened by studying the capacity of antibodies to tolerate dilution in enzyme immunoassay and reactivity with synthetic TPO/MPO peptides.

Keywords

Thyroid Disorder Autoimmune Thyroiditis Thyroid Peroxidase Postpartum Thyroiditis Vasculitic Disorder 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • A. M. Haapala
    • 1
  • H. Hyöty
    • 2
  • E. Soppi
    • 1
  • P. Parkkonen
    • 2
  • J. Mustonen
    • 3
  • A. Pasternack
    • 3
  1. 1.Division of Clinical Immunology Department of Clinical MicrobiologyUniversity Hospital of TampereFinland
  2. 2.Institute of Biomedical SciencesUniversity of TampereFinland
  3. 3.Department of Clinical SciencesUniversity of TampereFinland

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