Cross-Reactivity between Antibodies to Thyroid Microsomal Antigens and Myeloperoxidase
Antibodies against thyroid microsomal antigen (thyroid peroxidase, TMA/TPO) and myeloperoxidase (MPO) were measured from 115 patients with vasculitic disorders and 144 patients with suspected thyroid disorders. Nineteen patients, three with vasculitis and 16 with thyroid disorders, were shown to have both TPO and MPO antibodies, suggesting cross-reactivity of these antibodies. Their cross-reactivity was further strengtened by studying the capacity of antibodies to tolerate dilution in enzyme immunoassay and reactivity with synthetic TPO/MPO peptides.
KeywordsThyroid Disorder Autoimmune Thyroiditis Thyroid Peroxidase Postpartum Thyroiditis Vasculitic Disorder
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