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ANCA and IgG Subclasses

  • Mårten Segelmark
  • Jörgen Wieslander
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 336)

Summary

We studied IgG subclass distribution of ANCA in 247 patients with ELISA. We used monoclonal subclass specific antibodies and purified MPO and proteinase 3 as antigen. We found that IgG1 and IgG4 yield high values in both groups. We also found that high IgG2 titers were rare among the anti-proteinase 3 positive, while it was common among anti-MPO sera. In the assays for IgG3 the situation was the opposite.

Keywords

Positive Seron Rapidly Progressive Glomerulonephritis Alpha Granule Antineutrophil Cytoplasmic Autoantibody High IgG2 Titer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Wieslander, J., 1991, How are antineutrophil cytoplasmic autoantibodies detected? Am J Kidney Dis. XVIII: 154–158.Google Scholar
  2. 2.
    Falk, R.J., Terrell, R.S., Charles, L.A., Jennette, C., 1990, Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro, Proc Natl Acad Sci. USA 87: 4115–4119.PubMedCrossRefGoogle Scholar
  3. 3.
    Lai, K.N., Lockwood, C.M., 1991, The effect of anti-neutrophil cytoplasm autoantibodies on the signal transduction in human neutrophils, Clin Explmrrmnol. 85: 396–401.Google Scholar
  4. 4.
    Brouwer, E., Cohen Tervaert, J.W., Horst, G., Huitema, M.G., Van der Giessen, M., Limburg, P.C., Kallenberg, C.G.M., 1991, Predominance of IgGI and IgG4 subclasses of anti-neutrophil cytoplasmic autoantibodies (ANCA) in patients with Wegener’s granulomatosis and clinically related disorders, Clm Exp Immunol. 83: 379–36.Google Scholar
  5. 5.
    Jayne, D.R.W., Weetman, A.P., Lockwood, C.M., 1991, IgG subclass distribution of autoantibodies to neutrophil cytoplasmic antigens in systemic vasculitis, Clin Exp Immunol 84: 476–481.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Mårten Segelmark
    • 1
  • Jörgen Wieslander
    • 2
  1. 1.Department of NephrologyUniversity of LundLundSweden
  2. 2.Statens Serum InstitutCopenhagenDenmark

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