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A Novel Endogenous Amine, 1-Benzyl-1,2,3,4-Tetrahydroisoquinoline(1BnTIQ) in Parkinsonian CSF, and Its Toxicological Effect

  • Y. Tasaki
  • Y. Kotake
  • Y. Makino
  • S. Ohta
  • M. Hirobe
Part of the Advances in Behavioral Biology book series (ABBI, volume 44)

Abstract

Recently there have been many reports in which 1,2,3,4-tetrahydroisoquinoline (TIQ) derivatives may be related to the onset of Parkinson’s disease.1–12 In these reports, we have already confirmed that TIQ and 1-methyl-TIQ (1MeTIQ) were detected in the brains of mice, rats, and humans; and the 1MeTIQ content in the parkinsonian brain was decreased in comparison with that in a normal subject’s brain, though the TIQ content was not changed in between both brains.1,2,8,13 In addition, pretreatment with 1MeTIQ perfectly prevented mice treated with TIQ or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP) from bradykinesia, one of the characteristic symptoms in Parkinson’s disease. The slight difference in the structure between 1MeTIQ and TIQ, which is whether it has a methyl group at one position or not, induces a reverse effect (Figure 1).

Keywords

Tyrosine Hydroxylase Mouse Brain Toxicological Effect Pole Test Chronic Ethanol Treatment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Y. Tasaki
    • 1
  • Y. Kotake
    • 1
  • Y. Makino
    • 1
  • S. Ohta
    • 2
  • M. Hirobe
    • 1
  1. 1.Faculty of Pharmaceutical SciencesUniversity of TokyoBunkyo-ku, Tokyo 113Japan
  2. 2.Faculty of MedicineUniversity of TokyoBunkyo-ku, Tokyo 113Japan

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