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The in Vitro Formation of 1,3-Dimethyl-1,2,3,4-Tetrahydroisoquinoline, a Neurotoxic Metabolite of Amphetamines

  • Hanka Haber
  • Michael Collins
  • Matthias F. Melzig
Part of the Advances in Behavioral Biology book series (ABBI, volume 44)

Abstract

Since the early 1970s interest has been directed towards proposals suggesting the involvement of Pictet-Spengler condensation products, the tetrahydroisoquinolines (TIQ), in the aetiology of alcohol addiction. These products might be formed following alcohol consumption by a condensation between monoamine and an aldehyde, in particular, acetaldehyde. The most studied of all Pictet-Spengler condensation products is salsolinol (1-methyl-6,7-dihydroxy1,2,3,4-tetrahydroisoquinoline), the product of a direct cyclization between dopamine and acetaldehyde. The in vivo formation of tetrahydropapaveroline by the condensation between dopamine and its deaminated metabolite, 3,4-dihydroxyphenylacetaldehyde (dopaldehyde), has also been postulated (Figure 1).1

Keywords

Chronic Ethanol Pyridoxal Phosphate Isoquinoline Alkaloid Amine Concentration Full Scanning Mode 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Hanka Haber
    • 1
  • Michael Collins
    • 2
  • Matthias F. Melzig
    • 1
  1. 1.Research Institute of Molecular PharmacologyBerlinGermany
  2. 2.Stritch School of Medicine Department of Molecular BiologyLoyola University ChicagoMaywoodUSA

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