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Effect of Chronic Administration of 1,2,3,4-Tetrahydroisoquinoline and Its Derivatives on the Monkey: Immunohistochemical Study

  • Matsuo Ogawa
  • Ken-ichi Ogura
  • Yaeko Nagatsuka
  • Sigeru Ohta
  • Hisamasa Imai
  • Ikuko Nagatsu
  • Toshiharu Nagatsu
  • Mitsuo Yoshida
Part of the Advances in Behavioral Biology book series (ABBI, volume 44)

Abstract

Since 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was found to produce symptoms similar to Parkinson’s disease (Langston et al., 1983), toxins with structure similar to MPTP have been hypothesized to result in cell death of mesencephalic dopamine neurons. 1,2,3,4-Tetrahydroisoquinoline (TIQ) has a structure similar to MPTP, and it, and its derivatives exist as endogenous amines in human brain (Ohta et al., 1987; Niwa et al., 1987; Niwa et al., 1989). Toxic properties of TIQ on mitochondria are similar to those of MPP+ (the oxidative product of MPTP) (Suzuki et al., 1988). N-methyltetrahydroisoquinoline (NMTIQ) is formed from TIQ by N-methyltransferase (Naoi et al., 1989a). NMTIQ is oxidized by both type A and B monoamine oxidases, and the N-methylisoquinolinium ion (NMIQ+), the oxidative product, inhibits activities of enzymes related to catecholamine metabolism (Naoi et al., 1989b). NMTIQ and NMIQ+ inhibits complex I activity, similarly to TIQ, and this inhibitory potency of NMIQ+ on complex I activity is stronger than that of MPP+ (Suzuki et al., 1992). Recently, we administered TIQ and its derivatives (NMTIQ and NMIQ+) to monkeys and observed mesencephalic dopamine neurons immunohistochemically. Using light and electron microscopy we found that NMTIQ produces changes in mesencephalic dopamine neurons.

Keywords

Inclusion Body Monoamine Oxidase Biogenic Amine Diaminobenzidine Tetrahydrochloride Immunoreactive Neuron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Matsuo Ogawa
    • 1
  • Ken-ichi Ogura
    • 1
  • Yaeko Nagatsuka
    • 1
  • Sigeru Ohta
    • 2
  • Hisamasa Imai
    • 3
  • Ikuko Nagatsu
    • 4
  • Toshiharu Nagatsu
    • 5
  • Mitsuo Yoshida
    • 1
  1. 1.Department of NeurologyJichi Medical SchoolTochigiJapan
  2. 2.Department of Biochemistry and Nutrition, Faculty of MedicineTokyo UniversityTokyoJapan
  3. 3.Department of Neurology, School of MedicineJuntendo UniversityTokyoJapan
  4. 4.Department of Anatomy, School of MedicineFujita Health UniversityAichiJapan
  5. 5.Institute for Comprehensive Medical Science, School of MedicineFujita Health UniversityAichiJapan

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