Xanomeline: A Potent and Selective M1 Muscarinic Agonist in Vitro
Xanomeline (3-(4-Hexyloxy-1,2,5-thiadiazole-3-yl)-1,2,5,6-tetrahydro-1- methylpyridine), (hexyloxy-TZTP) was discovered in the course of investigations on the structure activity relationship of a series of thiadiazole based analogs of the muscarinic agonist arecoline. The compound demonstrated functional selectivity for M1 receptors when tested in isolated tissue preparations and in cloned cell lines expressing specific muscarinic receptor subtypes.
KeywordsMuscarinic Agonist Clone Cell Line Functional Selectivity Lilly Research Laboratory Muscarinic Receptor Type
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