Effect of Cortical Ischemic Damage on Primate Nucleus Basalis

  • Paolo Liberini
  • Claudio A. Cuello
Part of the Advances in Behavioral Biology book series (ABBI, volume 44)


The retrograde damage which occurs in rodent nucleus basalis magnocellularis (nbm) after a cortical devascularizing lesion is a useful experimental model to investigate the processes of retrograde degeneration (Cuello et al., 1986, 1989). This model has attracted remarkable attention because a marked loss of cholinergic neurons and a reduction of choline acetyltransferase activity (ChAT) in the cerebral cortex and nucleus basalis of Meynert (nbM) was detected in Alzheimer’s disease (AD) (Whitehouse et al., 1982; Arendt et al., 1983). The severity of these neuropathological changes affecting the cholinergic neurons within the basal forebrain follows a regional distribution which correlates with the degenerative changes observed in the neocortex receiving the corresponding projections (Mufson et al., 1989a). Several investigations indicate that the involvement of the nbM in this disease is most likely a result of primary cortical pathology resulting in a reduction of nerve growth factor (NGF) retrogradely transported (Appel 1981; Hefti and Weiner, 1986; Vogels et al, 1990). It has been extensively reported that the degeneration of these neurons and the accompanying loss of cholinergic projections to various cortical regions is related to the emerging cognitive impairment (Bartus et al., 1982; Damasio et al. 1989; Morris et al., 1992).


Nerve Growth Factor Excitatory Amino Acid Cholinergic Neuron Basal Forebrain Nucleus Basalis 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Paolo Liberini
    • 1
  • Claudio A. Cuello
    • 1
  1. 1.Department of Pharmacology and TherapeuticsMcGill UniversityMontrealCanada

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