Histochemical Demonstration of Monoamine Oxidase Activity in the Mouse Striatal Cholinergic Neurons and Marked Species Variations among Rodent Striata
Following systemic administration, MPTP is converted to the dopaminergic neurotoxin, MPP+, by MAO-B in the brain; and glial MAO-B in the striatum or substantia nigra has been suggested to be responsible for the metabolism of MPTP (Ransom et al., 1987; Kitahama et al., 1991). Thus, it would be important to investigate the histological localization of MAO in the striatum. Furthermore, the mouse has been most susceptible to MPTP dopaminergic toxicity among various rodent species (Heikkila et al., 1984). However, the histological localization of MAO in the mouse striatum is yet unknown. Recently, we have found MAO-containing neurons in C57BL/6 mouse striatum using MAO enzyme histochemistry. By double -labeling studies, we also demonstrated that these MAO-containing neurons were cholinergic in nature. In the present study, in order to investigate whether the presence of MAO activity in the striatal cholinergic neurons is specific to this strain, we examined various mouse strains and several other rodent species.
KeywordsMonoamine Oxidase Syrian Hamster Mongolian Gerbil Positive Neuron Histochemical Demonstration
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