Advertisement

Histochemical Demonstration of Monoamine Oxidase Activity in the Mouse Striatal Cholinergic Neurons and Marked Species Variations among Rodent Striata

  • Shinichi Nakamura
  • Hidekazu Tomimoto
  • Ichiro Akiguchi
  • Jun Kimura
Part of the Advances in Behavioral Biology book series (ABBI, volume 44)

Abstract

Following systemic administration, MPTP is converted to the dopaminergic neurotoxin, MPP+, by MAO-B in the brain; and glial MAO-B in the striatum or substantia nigra has been suggested to be responsible for the metabolism of MPTP (Ransom et al., 1987; Kitahama et al., 1991). Thus, it would be important to investigate the histological localization of MAO in the striatum. Furthermore, the mouse has been most susceptible to MPTP dopaminergic toxicity among various rodent species (Heikkila et al., 1984). However, the histological localization of MAO in the mouse striatum is yet unknown. Recently, we have found MAO-containing neurons in C57BL/6 mouse striatum using MAO enzyme histochemistry. By double -labeling studies, we also demonstrated that these MAO-containing neurons were cholinergic in nature. In the present study, in order to investigate whether the presence of MAO activity in the striatal cholinergic neurons is specific to this strain, we examined various mouse strains and several other rodent species.

Keywords

Monoamine Oxidase Syrian Hamster Mongolian Gerbil Positive Neuron Histochemical Demonstration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Arai, R., Kimura, H., and Maeda, T., 1986, Topographic atlas of monoamine oxidase-containing neurons in the rat brain studied by an improved histochemical method, Neuroscience, 19: 905–925.PubMedCrossRefGoogle Scholar
  2. Fowler, C. J., and Tipton, K. F., 1984a, On the substrate specificities of the two forms of monoamine oxidase, J. Pharm. Pharmacol. 36: 111–115.PubMedCrossRefGoogle Scholar
  3. Fowler, C. J., Oreland, L., Marcusson, J., and Winblad, B., 1984b, Titration of human brain monoamine oxidase-A ane -B by clorgyline and L-deprenyl, Naunyn-Schmiedeberg’s Arch Pharmacol. 311: 263–272.CrossRefGoogle Scholar
  4. Glover, V., Sandler, M., Owen, F. and Riley, G. J., 1977, Dopamine is a monoamine oxidase B substrate in man, Nature 265: 80–81.PubMedCrossRefGoogle Scholar
  5. Heikkila, R. E., Hess, A., and Duvoisin, R. C., 1984, Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1, 2, 5, 6-tetrahydropyridine in mice, Science 224: 1451–1453.PubMedCrossRefGoogle Scholar
  6. Kitahama, K., Denney, R. M., Maeda, T., and Jouvet, M., 1991, Distribution of type B monoamine oxidase immunoreactivity in the cat brain with reference to enzyme histochemistry, Neuroscience 44: 185–204.PubMedCrossRefGoogle Scholar
  7. Kubota, Y., Inagaki, S., Shimada, S., Kito, S., Eckenstein, F., and Tohyama, M., 1987, Neostriatal cholinergic neurons receive direct synaptic inputs from dopaminergic axons, Brain Res. 413: 179–184.PubMedCrossRefGoogle Scholar
  8. Nakamura, S., Akiguchi, I., and Kimura, J., 1993, The histochemical demonstration of MPTP oxidation in the postmortem human striatum, Neurosci. Lett. 154: 61–64.PubMedCrossRefGoogle Scholar
  9. Nakamura, S., Akiguchi, I., and Kimura, J., 1993, A subpopulation of mouse striatal cholinergic neurons show monoamine oxidase activity, Neurosci. Lett. 161: 141–144.PubMedCrossRefGoogle Scholar
  10. Ransom, B. R., Kunis, D. M., Irwin, I., and Langston, J. W., 1987, Astrocytes convert the parkinsonism inducing neurotoxin, MPTP, to its active metabolite, MPP*, Neurosci. Lett. 75: 323–328.PubMedCrossRefGoogle Scholar
  11. Westlund, K. N., Denney, R. M., Rose, R. M., and Abell, C. W., 1988, Localization of distinct monoamine oxidase A and monoamine oxidase B cell populations in the human brainstem, Neuroscience 25: 439–456.PubMedCrossRefGoogle Scholar
  12. Willoughby, J., Glover, V., Sandler, M., Albanese, M., Jenner, P., and Marsden, C. D., 1988, Monoamine oxidase activity and distribution in marmoset brain: implications for MPTP toxicity, Neurosci. Lett. 90: 100–106.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Shinichi Nakamura
    • 1
  • Hidekazu Tomimoto
    • 1
  • Ichiro Akiguchi
    • 1
  • Jun Kimura
    • 1
  1. 1.Department of Neurology Faculty of MedicineKyoto UniversityKyotoJapan

Personalised recommendations