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Positron Emission Tomography (PET) Studies with Ligands for Cholinergic Receptors in the Human Brain

  • Henrik Nybäck
  • Christer Halldin
  • Per Karlsson
  • Lars Eriksson
  • Arne Ahlin
  • Lars Müller
  • Lars Farde
Part of the Advances in Behavioral Biology book series (ABBI, volume 44)

Abstract

Using positron emission tomography (PET), the distribution and binding of radiolabelled ligands can be studied in the human brain in vivo (Comar et al., 1979). This technique has been applied for the study of dopamine (Wagner et al., 1983; Farde et al., 1989), benzodiazepine (Persson et al., 1985), and muscarinic acetylcholine (Frey et al., 1992) receptors. The development of methods for synthesis of radiolabelled nicotine (Mazière et al., 1976; Halldin et al.1992) made it possible to study brain uptake and distribution of this alkaloid by PET in animals (Ohno et al., 1976) and man (Nybäck et al., 1989; 1993). Although a diminished brain uptake of [11C]-nicotine has been found in Alzheimer patients as compared to healthy subjects (Nordberg et al., 1991), it has not been demonstrated that this decline is due to loss of specific nicotinic receptors. The decline may as well be brought about by general tissue loss and decreased cerebral blood flow associated with the degenerative disease process. The recent development of substituted thiadiazole-methylpyridines (TZTP) as specific M1 muscarinic agonists and their labelling with [11C] (Halldin et al., 1993) has offered new possibilities for treatment attempts and for diagnostic imaging of neurodegenerative disorders.

Keywords

Positron Emission Tomography Alzheimer Patient Nicotinic Receptor Brain Uptake Nicotine Uptake 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Henrik Nybäck
    • 1
  • Christer Halldin
    • 1
  • Per Karlsson
    • 1
  • Lars Eriksson
    • 1
  • Arne Ahlin
    • 1
  • Lars Müller
    • 1
  • Lars Farde
    • 1
  1. 1.Department of Clinical Neuroscience Psychiatry and Psychology SectionKarolinska Hospital and InstituteStockholmSweden

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