A Novel Gene Delivery System for Neuroactive Peptides in Brain Tissue
The development of a gene delivery system that permits long term, stable expression in brain tissue would be an important step for treating long term neuropathological disorders such as Alzheimer’s disease. Conceivably, such a system could reduce levels of neurotoxic gene-products (e.g., amyloid precursor protein) through infusion of appropriate antisenseconstructs, or counteract disease-induced losses in neurotransmission/ trophism through exogenous gene-induced peptide synthesis.
KeywordsGene Delivery System Sendai Virus Neuroactive Peptide Region Dependent Manner Sendai Virus Envelope
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