Abstract
The development of a gene delivery system that permits long term, stable expression in brain tissue would be an important step for treating long term neuropathological disorders such as Alzheimer’s disease. Conceivably, such a system could reduce levels of neurotoxic gene-products (e.g., amyloid precursor protein) through infusion of appropriate antisenseconstructs, or counteract disease-induced losses in neurotransmission/ trophism through exogenous gene-induced peptide synthesis.
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Meyer, E.M. et al. (1995). A Novel Gene Delivery System for Neuroactive Peptides in Brain Tissue. In: Hanin, I., Yoshida, M., Fisher, A. (eds) Alzheimer’s and Parkinson’s Diseases. Advances in Behavioral Biology, vol 44. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9145-7_100
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DOI: https://doi.org/10.1007/978-1-4757-9145-7_100
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