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Alcohol and the Brain pp 19–68Cite as

Ethanol’s Action on Brain Biochemistry

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Abstract

It is generally assumed that ethanol exerts its effects in the central nervous system (CNS) by perturbing the normal processes of information conduction and transmission. Using electrophysiologic techniques, one can directly assess the effects of ethanol on neuronal activity, and such studies have been performed (e.g., see reference 1). However, insights into the molecular mechanisms by which ethanol affects neuronal activity have, at present, been derived primarily from neurochemical assessments of ethanol’s actions. In the CNS, as in the peripheral nervous system, rates of neurotransmitter metabolism usually reflect the level of neuronal activity,2,3 and one can assess responses to ethanol by determining ethanol’s effect on neurotransmitter synthesis, release, and metabolism and/or by measuring the interactions of neurotransmitters with specific receptors in the presence of ethanol. The results of such studies provide the basis for this review.

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Authors and Affiliations

  1. Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, 20205, USA

    Paula L. Hoffman & Boris Tabakoff

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  1. Paula L. Hoffman
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  2. Boris Tabakoff
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Editors and Affiliations

  1. Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 15213, Pittsburgh, Pennsylvania, USA

    Ralph E. Tarter Ph.D.

  2. Department of Medicine, Division of Gastroenterology, University of Pittsburgh School of Medicine, 15261, Pittsburgh, Pennsylvania, USA

    David H. van Thiel M.D.

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© 1985 Springer Science+Business Media New York

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Hoffman, P.L., Tabakoff, B. (1985). Ethanol’s Action on Brain Biochemistry. In: Tarter, R.E., van Thiel, D.H. (eds) Alcohol and the Brain. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9134-1_2

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  • DOI: https://doi.org/10.1007/978-1-4757-9134-1_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9136-5

  • Online ISBN: 978-1-4757-9134-1

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