Some Therapeutic Implications of the Crosslinkage Theory of Aging

  • Johan Bjorksten
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 86)


The concept of crosslinkages as the base for aging was suggested by Bjorksten (1941), who in 1942 expressed this theory as follows: “The aging of living organisms I believe is due to the occasional formation by tanning, of bridges between protein molecules, which cannot be broken by the cell enzymes. Such irreparable tanning may be caused by tanning agents foreign to the organism or formed by unusual biological side reactions, or it may be due to the formation of a tanning bridge in some particular position in the protein molecule. In either event, the result is that cumulative tanning of body proteins which we know as old age.” If we add the words “and nucleic acids” to “proteins” this still covers the tenets of the crosslinking theory.


Starch Agar Carbohydrate Transportation Aldehyde 
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© Springer Science+Business Media New York 1977

Authors and Affiliations

  • Johan Bjorksten
    • 1
  1. 1.Bjorksten Research FoundationMadisonUSA

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