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Prolactin and Autoimmunity: Influences of Prolactin in Systemic Lupus Erythematosus

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Advances in Psychoneuroimmunology

Part of the book series: Hans Selye Symposia on Neuroendocrinology and Stress ((HSSN,volume 3))

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Abstract

The autoimmune disease, systemic lupus erythematosus (SLE), is incurable, and individuals with this illness are at risk of severe and potentially fatal involvement of the central nervous system and kidneys.1,2 SLE occurs most commonly in women of childbearing age, and evidence has suggested that this disease is influenced by reproductive hormones.3 Recent studies in this laboratory have employed a hormone-sensitive murine model of SLE, the NZB X NZW (B/W) mouse,4 to investigate the role of the lactotrope, prolactin,5,6 in spontaneously occurring autoimmune disease. This report will summarize our findings in groups of female B/W mice made hyperprolactinemic or, conversely, treated with bromocriptine, an inhibitor of prolactin secretion.7

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Authors and Affiliations

  1. Department of Internal Medicine, University of Missouri-Columbia, Columbia, MO, 65201-5297, USA

    Sara E. Walker, Susan H. Allen, Robert W. Hoffman & Robert W. McMurray

  2. Department of Pathology, School of Medicine, University of Missouri-Columbia, Columbia, MO, 65201-5297, USA

    Robert W. Hoffman

  3. Department of Animal Sciences, University of Missouri-Columbia, Columbia, MO, 65201-5297, USA

    Duane H. Keisler

  4. The College of Veterinary Medicine, University of Missouri-Columbia, Columbia, MO, 65201-5297, USA

    Cynthia L. Besch-Williford

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  1. Sara E. Walker
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  4. Cynthia L. Besch-Williford
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Editors and Affiliations

  1. Department of Immunology, The University of Manitoba, Winnipeg, Manitoba, Canada

    Istvan Berczi

  2. National Institute of Haematology, Blood Transfusion and Immunology, Budapest, Hungary

    Judith Szélenyi

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Walker, S.E., Keisler, D.H., Allen, S.H., Besch-Williford, C.L., Hoffman, R.W., McMurray, R.W. (1994). Prolactin and Autoimmunity: Influences of Prolactin in Systemic Lupus Erythematosus. In: Berczi, I., Szélenyi, J. (eds) Advances in Psychoneuroimmunology. Hans Selye Symposia on Neuroendocrinology and Stress, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9104-4_9

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