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Prolactin and Autoimmunity: Influences of Prolactin in Systemic Lupus Erythematosus

  • Sara E. Walker
  • Duane H. Keisler
  • Susan H. Allen
  • Cynthia L. Besch-Williford
  • Robert W. Hoffman
  • Robert W. McMurray
Part of the Hans Selye Symposia on Neuroendocrinology and Stress book series (HSSN, volume 3)

Abstract

The autoimmune disease, systemic lupus erythematosus (SLE), is incurable, and individuals with this illness are at risk of severe and potentially fatal involvement of the central nervous system and kidneys.1,2 SLE occurs most commonly in women of childbearing age, and evidence has suggested that this disease is influenced by reproductive hormones.3 Recent studies in this laboratory have employed a hormone-sensitive murine model of SLE, the NZB X NZW (B/W) mouse,4 to investigate the role of the lactotrope, prolactin,5,6 in spontaneously occurring autoimmune disease. This report will summarize our findings in groups of female B/W mice made hyperprolactinemic or, conversely, treated with bromocriptine, an inhibitor of prolactin secretion.7

Keywords

Systemic Lupus Erythematosus Systemic Lupus Erythematosus Patient Serum Prolactin Ethinyl Estradiol Prolactin Secretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Sara E. Walker
    • 1
  • Duane H. Keisler
    • 3
  • Susan H. Allen
    • 1
  • Cynthia L. Besch-Williford
    • 4
  • Robert W. Hoffman
    • 1
    • 2
  • Robert W. McMurray
    • 1
  1. 1.Department of Internal MedicineUniversity of Missouri-ColumbiaColumbiaUSA
  2. 2.Department of Pathology, School of MedicineUniversity of Missouri-ColumbiaColumbiaUSA
  3. 3.Department of Animal SciencesUniversity of Missouri-ColumbiaColumbiaUSA
  4. 4.The College of Veterinary MedicineUniversity of Missouri-ColumbiaColumbiaUSA

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