Mechanisms of Stress-Induced Host Defense Alterations
The initial processing and subsequent physiological response to an aversive situation or environmental cues previously associated with an aversive situation (conditioned stimuli) occurs within the brain. Using experimental models, many of the areas of the brain which respond to a stressor have been identified. The role of neurohormones within the brain and the participation of the sympathetic nervous system in altering immune function is also beginning to be clarified. The primary interest of our research laboratory is to understand the mechanisms which are activated after a subject experiences a stressor and the resultant alteration of immune system function.
KeywordsNatural Killer Cell Conditioned Stimulus Sympathetic Nervous System Peripheral Blood Lymphocyte Locus Coeruleus
Unable to display preview. Download preview PDF.
- 1.B.S. Rabin, J.E. Cunnick, and D.T. Lysle, Stress-induced alteration of immune function, Progress in Neuro Endocrin Immunology. 3:116 (1990)Google Scholar
- 3.D.T. Lysle, J.E. Cunnick, B.J. Kucinski, H. Fowler, and B.S. Rabin, Characterization of immune alterations induced by a conditioned aversive stimulus, Psychobiol. 18:220 (1990)Google Scholar
- 6.M.A. Pezzone, H. Dohanics, J.G. Verbalis, and B.S. Rabin, Effects of footshock stress upon spleen and peripheral blood lymphocyte mitogenic responses in paraventricular nucleus (PVN) lesioned rats, Society for Neuroscience Abstracts. 18:679 (1992).Google Scholar
- 15.B. Crary, M. Borysenko, D.C. Sutherland, I. Kutz, J.S. Borysenko, and H. Benson, Decrease in mitogen responsiveness of mononuclear cells from peripheral blood after epinephrine administration in humans, Journal of Immunology. 130:694 (1983).Google Scholar
- 16.A.S. Maisel, K.U. Knowlton, P. Fowler, A. Reardon, M.G. Ziegler, H.J. Motulsky, P.A. Insel, and M.C. Michel, Adrenergic control of circulating lymphocyte subpopulations. Effects of congestive heart failure, dynamic exercise, and terbutaline treatment, Journal of Clinical Investigation. 85:462 (1990).PubMedCrossRefGoogle Scholar
- 17.L.J.H. van Tits, M.C. Michel, H. Grosse-Wilde, M. Happel, F.W. Eigler, A. Soliman, and O.E. Brodde, Catecholamines increase lymphocyte b2-adrenergic receptors via a b2-adrenergic, spleen dependent process, American Journal of Physiology. 258:E191 (1990).Google Scholar
- 18.A. Miller, Presented at the Fourth Research Perspectives in Immunology Meeting, Boulder, Colorado, (1993).Google Scholar
- 19.E. Fride, Y. Han, J. Feldon, G. Halevy, and M. Weinstock, Effects of prenatal stress on vulnerability to stress in prepubertal and adult rats, Psychological Behavior. 37:681 (1986).Google Scholar