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Advances in Psychoneuroimmunology pp 317–322Cite as

Neuroendocrine Aspects of Lymphocyte Migration

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Part of the book series: Hans Selye Symposia on Neuroendocrinology and Stress ((HSSN,volume 3))

Abstract

Lymphocyte migration plays a central role in adaptive responses because it permits the continuous redeployment of specialist lymphocytes between different compartments of the body. Through this process, the immune system undergoes dynamic remodelling in response to physiological and antigenic challenges. There have been rapid advances in our understanding of the cellular and molecular features that contribute to migration of lymphocytes in vivo, which are well reviewed elsewhere.1,2 It is now traditional to consider the first step in lymphoid migratory behaviour to be the exit of the cells from the blood stream. In lymph nodes, Peyer’s patches and virtually all other tissues of the body with the exception of the spleen, lymphocytes leave the cardiovascular system via the postcapillary venules (PCV),3 and the attachment of migrating lymphocytes to the endothelium depends upon the reciprocal interaction of adhesion molecules at the surface of these cells.4,5

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Authors and Affiliations

  1. Department of Medicine, University of Toronto, Toronto, Ontario, Canada

    C. A. Ottaway

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  1. C. A. Ottaway
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Editors and Affiliations

  1. Department of Immunology, The University of Manitoba, Winnipeg, Manitoba, Canada

    Istvan Berczi

  2. National Institute of Haematology, Blood Transfusion and Immunology, Budapest, Hungary

    Judith Szélenyi

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© 1994 Springer Science+Business Media New York

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Ottaway, C.A. (1994). Neuroendocrine Aspects of Lymphocyte Migration. In: Berczi, I., Szélenyi, J. (eds) Advances in Psychoneuroimmunology. Hans Selye Symposia on Neuroendocrinology and Stress, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9104-4_27

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  • DOI: https://doi.org/10.1007/978-1-4757-9104-4_27

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9106-8

  • Online ISBN: 978-1-4757-9104-4

  • eBook Packages: Springer Book Archive

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