Advertisement

Neuroendocrine Aspects of Lymphocyte Migration

  • C. A. Ottaway
Part of the Hans Selye Symposia on Neuroendocrinology and Stress book series (HSSN, volume 3)

Abstract

Lymphocyte migration plays a central role in adaptive responses because it permits the continuous redeployment of specialist lymphocytes between different compartments of the body. Through this process, the immune system undergoes dynamic remodelling in response to physiological and antigenic challenges. There have been rapid advances in our understanding of the cellular and molecular features that contribute to migration of lymphocytes in vivo, which are well reviewed elsewhere.1,2 It is now traditional to consider the first step in lymphoid migratory behaviour to be the exit of the cells from the blood stream. In lymph nodes, Peyer’s patches and virtually all other tissues of the body with the exception of the spleen, lymphocytes leave the cardiovascular system via the postcapillary venules (PCV),3 and the attachment of migrating lymphocytes to the endothelium depends upon the reciprocal interaction of adhesion molecules at the surface of these cells.4,5

Keywords

Large Granular Lymphocyte Postcapillary Venule Lymphocyte Migration Sympathoadrenal Activation Splenic White Pulp 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    M. Dustin and T. Springer, Role of lymphocyte adhesion receptors in transient interactions and cell locomotion, Annu. Rev. Immunol. 9:27 (1991).PubMedCrossRefGoogle Scholar
  2. 2.
    L. Picker and E. Butcher, Physiological and molecular mechanisms of lymphocyte homing, Annu. Rev. Immunol. 10:561 (1992).PubMedCrossRefGoogle Scholar
  3. 3.
    C.A. Ottaway, Dynamic aspects of lymphoid cell migration, in: “Migration and Homing of Lymphoid Cells,” vol. II, A.J. Husband, ed., CRC Press, Boca Raton, FL (1988).Google Scholar
  4. 4.
    R.O. Haynes, Integrins: versatility, modulation and signaling in cell adhesion, Cell 69:11 (1992).CrossRefGoogle Scholar
  5. 5.
    C.R. Mackay and B. Imhof, Cell adhesion in the immune system, Immunol. Today 14:99 (1993).PubMedCrossRefGoogle Scholar
  6. 6.
    C.A. Ottaway and A.J. Husband, Central nervous system influences on lymphocyte migration, Brain Behav. Immun. 6:97 (1992).PubMedCrossRefGoogle Scholar
  7. 7.
    D. Feiten, K. Ackerman, S. Weigand and S. Feiten, Noradrenergic sympathetic innervation of the spleen. I. Nerve fibers associate with lymphocytes and macrophages in specific compartments of the white pulp, J. Neurosci. Res. 18:28 (1987).CrossRefGoogle Scholar
  8. 8.
    S. Feiten, D. Feiten, D. Bellinger, S. Carlson, K. Ackerman and K. Madden, Noradrenergic sympathetic innervation of lymphoid organs, Prog. Allergy 43:14 (1988).Google Scholar
  9. 9.
    O. Lundgren and I. Wallentin, Local chemical and nervous control of consecutive sections in the mesenteric lymph node of the cat, Angiologica 1:284 (1964).PubMedGoogle Scholar
  10. 10.
    S. Feiten and J. Olschowka, Noradrenergic sympathetic innervation of the spleen. II. Tyrosine hydroxylase positive nerve terminals form synaptic-like contacts on lymphocytes in the splenic white pulp, J. Neurosci. Res. 18:37 (1987).CrossRefGoogle Scholar
  11. 11.
    T. Moore, Modification of lymphocyte traffic by neurotransmitter substances, Immunology 52:511 (1984).PubMedGoogle Scholar
  12. 12.
    M. Loeper and O. Crouzon, L’action de l’adrenaline sur le sang, Arch. Med. Exp. 16:83 (1904).Google Scholar
  13. 13.
    D. Feiten, S. Feiten, D. Bellinger, S. Carlson, K. Ackerman and K. Madden, Noradrenergic sympathetic neural interactions with the immune system: structure and function, Immunol. Rev. 100:225 (1987).CrossRefGoogle Scholar
  14. 14.
    D. McCarthy and M. Dale, The leukocytosis of exercise, Sports Med. 6:333 (1988).PubMedCrossRefGoogle Scholar
  15. 15.
    A. Kendall, L. Hoffman-Goetz, M. Houston, B. MacNeil and Y. Arumugam, Exercise and blood lymphocyte subset responses: intensity, duration, and subject fitness effects, J. Appl. Physiol. 69:251 (1990).PubMedGoogle Scholar
  16. 16.
    A. Gray, Y. Smart, R. Telford, M. Weidemann and T. Roberts, Anaerobic exercise causes transient changes in leukocyte subsets and IL-2R expression, Med. Sci. Sports Exerc. 24:1332 (1990).Google Scholar
  17. 17.
    R. Benschop, F. Oostveen, C. Heijnen and R. Ballieux, Beta-adrenergic stimulation causes detachment of natural killer cells from cultured endothelium, Eur. J. Immunol. 23:3242 (1993).PubMedCrossRefGoogle Scholar
  18. 18.
    S. Bourdoulous, O. Durieu-Trautmann, A. Strosberg and P. Courand, Catecholamines stimulate MHC Class I, Class II and invariant chain gene expression in brain endothelium through different mechanisms, J. Immunol. 150:1486 (1993).PubMedGoogle Scholar
  19. 19.
    J. Pober, M. Slowik, L. De Luca and A. Ritchie, Elevated cyclic AMP inhibits endothelial cell synthesis and expression of TNF-induced endothelial leukocyte adhesion molecule-1, and vascular cell adhesion molecule-1, but not intracellular adhesion molecule-1, J. Immunol. 150:5114 (1993).PubMedGoogle Scholar
  20. 20.
    E. Bachen, S. Manuck, A. Marsland, S. Cohen, S. Malkoff, M. Muldoon and B. Rabin, Lymphocyte subset and cellular immune responses to a brief experimental stressor, Psychosom. Med. 54:673 (1992).PubMedGoogle Scholar
  21. 21.
    P. Knapp, E. Levy, R. Giorgi, P. Black, B. Fox and T. Heeren, Short-term immunological effects of induced emotion, Psychosom. Med. 54:133 (1992).PubMedGoogle Scholar
  22. 22.
    T. Bennet-Herbert and S. Cohen, Stress and immunity in humans: a meta-analytic review, Psychosom. Med. 55:364 (1993).Google Scholar
  23. 23.
    A. Fauci and D. Dale, The effect of hydrocortisone on the kinetics of normal human lymphocytes, Blood 46:235 (1975).PubMedGoogle Scholar
  24. 24.
    A. Fauci, Mechanisms of corticosteroid action on lymphocyte subpopulations, Immunology 28:669 (1975).PubMedGoogle Scholar
  25. 25.
    J. Slade and B. Hepburn, Prednisone induced alterations of circulating human lymphocyte subsets, J. Lab. Clin. Med. 101:479 (1983).PubMedGoogle Scholar
  26. 26.
    L. Fisher, E. Ludwig, J. Wald, R. Sloan, E. Middleton and W. Jusko, Pharmacokinetics and pharmacodynamics of methylprednisolone when administered at 8 a.m. versus 4 p.m., Clin. Pharmacol. Ther. 51:677 (1992).PubMedCrossRefGoogle Scholar
  27. 27.
    J. Cox and W. Ford, The migration of lymphocytes across specialized vascular endothelium IV. Prednisolone acts at several points on the recirculation pathway of lymphocytes, Cell. Immunol. 66:407 (1982).PubMedCrossRefGoogle Scholar
  28. 28.
    H. Chung, W. Samlowski and R. Daynes, Modification of the murine immune system by glucocorticosteroids: alterations of the tissue localization properties of circulating lymphocytes, Cell. Immunol. 101:571 (1986).PubMedCrossRefGoogle Scholar
  29. 29.
    B. Cronstein, S. Kimmel, R. Levin, F. Martiniuk and G. Weissmann, A mechanism for the antiinflammatory effects of corticosteroids: the glucoccorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule, Proc. Natl. Acad. Sci. USA 89:9991 (1992).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • C. A. Ottaway
    • 1
  1. 1.Department of MedicineUniversity of TorontoTorontoCanada

Personalised recommendations