Expression of Cholinergic Structures on Lymphocytes
A number of receptors, surface markers and enzymes are known to be expressed commonly on cells of nervous-, neuroendocrine- and immune-systems. The presence of cholinergic structures, i.e. muscarinic (mAChR) and nicotinic (nAChR) receptors as well as acetylcholinesterase (AChE) on peripheral blood lymphocytes (PBLs) was reported by several authors.1–4 As might be expected, lymphocytes respond to parasympathetic signals. mAChR agonists increase PBL motility and Chemotaxis,5,6 rosette formation7 and proliferation2 while unilateral parasympathectomy results in decreased plaque-forming cell response in submandibular lymph nodes.8 In vitro inhibition of AChE results in decreased T-cell rosette formation9 while the in vivo administration of physostigmine increases the number of plaque-forming cells.10
KeywordsPeripheral Blood Lymphocyte AChE Activity Nicotinic Acetylcholine Receptor Senile Dementia Muscarinic Acetylcholine Receptor
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- 18.L. Bonomo, S. Antonici, and E. Jiriollo, Cell mediated immune response in the elderly, Bull. Inst. Pasteur 81:347 (1983).Google Scholar