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Glucocorticoid Regulation of Mucosal Immunity: Effect of Dexamethasone on IgA and Secretory Component (SC)

  • Charles R. Wira
  • Richard Rossoll
Part of the Hans Selye Symposia on Neuroendocrinology and Stress book series (HSSN, volume 3)

Abstract

Immunoglobulin A (IgA), the predominant immunoglobulin at mucosal surfaces of the body, is produced on a daily basis in amounts greater than all other immunoglobulins combined1. As the first line of defense, IgA at mucosal surfaces protects against bacterial and viral infection by antibody interactions which either destroy pathogens or block their adherence to prevent potentially infective agents from entering the body2. To reach mucosal sites, IgA binds to secretory component (SC), the cytoplasmic portion of the polymeric Ig receptor that is synthesized by rat hepatocytes and epithelial cells lining the mucosal surfaces of the body3–6. Following binding, polymeric IgA (pIgA) is transported from serum into the gastrointestinal tract via bile and from tissues into secretions of the respiratory, gastrointestinal and urogenital tracts7–10. Transport through hepatocytes and epithelial cells is similar in that IgA binds covalently to SC and following endocytosis, is released as pIgA-SC complex (secretory IgA)10–11.

Keywords

High Performance Liquid Chromatography Mucosal Surface Female Reproductive Tract Mucosal Immune System Secretory Component 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Charles R. Wira
    • 1
  • Richard Rossoll
    • 1
  1. 1.Department of PhysiologyDartmouth Medical SchoolLebanonUSA

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