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Glucocorticoid Regulation of Mucosal Immunity: Effect of Dexamethasone on IgA and Secretory Component (SC)

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Book cover Advances in Psychoneuroimmunology

Part of the book series: Hans Selye Symposia on Neuroendocrinology and Stress ((HSSN,volume 3))

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Abstract

Immunoglobulin A (IgA), the predominant immunoglobulin at mucosal surfaces of the body, is produced on a daily basis in amounts greater than all other immunoglobulins combined1. As the first line of defense, IgA at mucosal surfaces protects against bacterial and viral infection by antibody interactions which either destroy pathogens or block their adherence to prevent potentially infective agents from entering the body2. To reach mucosal sites, IgA binds to secretory component (SC), the cytoplasmic portion of the polymeric Ig receptor that is synthesized by rat hepatocytes and epithelial cells lining the mucosal surfaces of the body3–6. Following binding, polymeric IgA (pIgA) is transported from serum into the gastrointestinal tract via bile and from tissues into secretions of the respiratory, gastrointestinal and urogenital tracts7–10. Transport through hepatocytes and epithelial cells is similar in that IgA binds covalently to SC and following endocytosis, is released as pIgA-SC complex (secretory IgA)10–11.

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Authors and Affiliations

  1. Department of Physiology, Dartmouth Medical School, Lebanon, NH, 03756, USA

    Charles R. Wira & Richard Rossoll

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  1. Charles R. Wira
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  2. Richard Rossoll
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Editors and Affiliations

  1. Department of Immunology, The University of Manitoba, Winnipeg, Manitoba, Canada

    Istvan Berczi

  2. National Institute of Haematology, Blood Transfusion and Immunology, Budapest, Hungary

    Judith Szélenyi

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© 1994 Springer Science+Business Media New York

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Wira, C.R., Rossoll, R. (1994). Glucocorticoid Regulation of Mucosal Immunity: Effect of Dexamethasone on IgA and Secretory Component (SC). In: Berczi, I., Szélenyi, J. (eds) Advances in Psychoneuroimmunology. Hans Selye Symposia on Neuroendocrinology and Stress, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9104-4_16

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  • DOI: https://doi.org/10.1007/978-1-4757-9104-4_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9106-8

  • Online ISBN: 978-1-4757-9104-4

  • eBook Packages: Springer Book Archive

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