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Interleukin Involvement in the Regulation of Pituitary Cell Growth

  • E. Arzt
  • J. Sauer
  • U. Renner
  • G. K. Stalla
Part of the Hans Selye Symposia on Neuroendocrinology and Stress book series (HSSN, volume 3)

Abstract

After the first description by Besedovsky et al.1 of the stimulatory action of interleukin-1 (IL-1) on the secretion of hormones by the hypothalamic-pituitary-adrenocortical (HPA) axis, the action of this and other cytokines have been extensively studied. IL-1 is the most potent cytokine stimulating the axis. As we will concentrate on other aspects of cytokine action, it is beyond the scope of this chapter to review the action of cytokines on hormone secretion. It is now well accepted that these cytokines not only constitute a lymphocyte message but also that they are autocrine and paracrine factors in the regulation of the HPA axis, especially the pituitary. We will start with a brief description about the intrinsic expression of interleukins and their receptors on neuro-endorine tissues and then concentrate on their effects on the growth of these cells.

Keywords

Pituitary Adenoma Pituitary Cell Anterior Pituitary Cell Pituitary Carcinoma Human Pituitary Adenoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    H. Besedovsky, A. Del Rey, E.C.A. Sorkin and C.D. Dinarello, Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones, Science 233:652 (1986).PubMedCrossRefGoogle Scholar
  2. 2.
    C.D. Breder, C.A. Dinarello and C.B. Saper, Interleukin-1 immunoreactive innervation of the human hypothalamus, Science 240:321 (1988).PubMedCrossRefGoogle Scholar
  3. 3.
    B.L. Spangelo, A.M. Judd, R.M. MacLeod, D.W. Goodman and P.C. Isakson, Endotoxin-induced release of interleukin-6 from rat medial basal hypothalami, Endocrinology 127:1779 (1990).PubMedCrossRefGoogle Scholar
  4. 4.
    J.I. Koenig, K. Snow, B.D. Clark, R. Toni, J.G. Cannon, A.R. Shaw, C.A. Dinarello, S. Reichlin, S.L. Lee and R.M. Lechan, Intrinsic pituitary IL-1b is induced by bacterial LPS, Endocrinology 126:3053 (1990).PubMedCrossRefGoogle Scholar
  5. 5.
    E.B. De Souza, E.L. Webster, D.E. Grigoriadis and D.E. Tracey, Corticotropin-releasing factor (CRF) and interleukin-1 (IL-1) receptors in the brain-pituitary-immune axis, Psychopharmacol. Bull. 25:299 (1989).PubMedGoogle Scholar
  6. 6.
    J. Bristulf, A. Simoncsits and T. Bartfai, Characterization of a neuronal interleukin-1 receptor and the corresponding mRNA in the mouse anterior pituitary cell line AtT-20, Neurosci. Lett. 128:173 (1991).PubMedCrossRefGoogle Scholar
  7. 7.
    H. Vankelecom, P. Carmeliet, J. Van Damme, A. Billiau and C. Denef, Production of IL-6 by folliculostellate cells of the anterior pituitary gland in a histiotypic cell aggregate culture system, Neuroendocrinology 49:102 (1989).PubMedCrossRefGoogle Scholar
  8. 8.
    B.L. Spangelo, R.M. MacLeod and P.C. Isakson, Production of interleukin-6 by anterior pituitary cells in vitro, Endocrinology 126:582 (1990).PubMedCrossRefGoogle Scholar
  9. 9.
    B.L. Spangelo, A.M. Judd, P.C. Isakson and R.M. MacLeod, Interleukin-1 stimulates interleukin-6 release from rat anterior pituitary cells in vitro, Endocrinology 128:2685 (1991).PubMedCrossRefGoogle Scholar
  10. 10.
    M. Yamaguchi, N. Matsuzaki, K. Hirota, A. Miyake and O. Tanizawa, Interleukin 6 possibly induced by interleukin lb in the pituitary gland stimulates the release of gonadotropins and prolactin, Acta Endocrinol (Copenh.) 122:201 (1990).Google Scholar
  11. 11.
    B. Velkeniers, G. D’Haens, G. Smets, P. Vergani, L. Vanhaelst and E.L. Hooghe-Peters, Expression of IL-6 mRNA in corticotroph cell adenomas, J. Endocrinol. Invest. 14 (Suppl. 1) 31 (Abstr.) (1991).Google Scholar
  12. 12.
    T.H. Jones, S. Justice, A. Price and K. Chapman, Interleukin-6 secreting human pituitary adenomas in vitro, J. Clin. Endocrinol. Metab. 73:207 (1991).PubMedCrossRefGoogle Scholar
  13. 13.
    S. Tsagarakis, G. Kontogeorgeos, P. Giannou, N. Thalassinos, J. Woolley, G.M. Besser and A. Grossman, Interleukin-6, a growth promoting cytokine, is present in human pituitary adenomas: an immunocytochemical study, Clin. Endocrinol. 37:163 (1992).CrossRefGoogle Scholar
  14. 14.
    M. Ohmichi, K. Hirota, K. Koike, H. Kurachi, S. Ohtsuka, N. Matsuzaki, M. Yamaguchi, A. Miyake and O. Tanizawa, Binding sites for interleukin-6 in the anterior pituitary gland, Neuroendocrinology 55:199 (1992).PubMedCrossRefGoogle Scholar
  15. 15.
    E. Arzt, G. Stelzer, U. Renner, M. Lange, O.A. Muller and G.K. Stalla, Interleukin-2 and IL-2 receptor expression in human corticotrophic adenoma and murine pituitary cell cultures, J. Clin. Invest. 90:1944 (1992).PubMedCrossRefGoogle Scholar
  16. 16.
    E. Arzt, R. Buric, G. Stelzer, J. Stalla, J. Sauer, U. Renner and G.K. Stalla, Interleukin involvement in anterior pituitary cell growth regulation: effects of interleukin-2 and interleukin-6, Endocrinology 132:459 (1993).PubMedCrossRefGoogle Scholar
  17. 17.
    S. Karanth and S.M. McCann, Anterior pituitary hormone control by interleukin-2, Proc. Natl. Acad. Sci. USA 88:2961 (1991).PubMedCrossRefGoogle Scholar
  18. 18.
    S. Karanth, The influence of dopamine (DA) on interleukin-2 induced release of prolactin (PRL), luteinizing hormone (LH) and follicle stimulating hormone (FSH) by the anterior pituitary, Program of the 73rd Annual Meeting of The Endocrine Society, Washington, D.C., p. 210 (Abstr.) (1991).Google Scholar
  19. 19.
    R.J. Robb, Interleukin 2: the molecule and its function, Immunol. Today 5:203 (1984).CrossRefGoogle Scholar
  20. 20.
    M. Helle, J.P.J. Brakenhoff, E.R. Degroot and L.A. Aarden, Interleukin-6 is involved in interleukin-1 induced activities, Eur. J. Immunol. 18:957 (1988).PubMedCrossRefGoogle Scholar
  21. 21.
    T. Kishomoto, The biology of interleukin-6, Blood 74:1 (1989).Google Scholar
  22. 22.
    L. Chen, L.M. Shulman and M. Revel, IL-6 receptors and sensitivity to growth inhibition by IL-6 in clones of human breast carcinoma cells, J. Biol. Reg. Homeos. Agents 5:125 (1991).Google Scholar
  23. 23.
    J. Merrill, Macroglia: neural cells responsive to lymphokines and growth factors, Immunol. Today 8:146 (1987).CrossRefGoogle Scholar
  24. 24.
    E.N. Benveniste and J.E. Merrill, Stimulation of oligodendroglial proliferation and maturation by interleukin-2, Nature 321:610 (1986).PubMedCrossRefGoogle Scholar
  25. 25.
    R.P. Saneto, A. Altman, R.L. Knobler, H.M. Johnson and J. de Vellis, Interleukin-2 mediates the inhibition of oligodendrocyte progenitor cell proliferation in vitro, Proc. Natl. Acad. Sci. USA 83:9221 (1986).PubMedCrossRefGoogle Scholar
  26. 26.
    P.K. Haugen and P.C. Letourneau, Interleukin-2 enhances chick and rat sympathetic, but not sensory, neurite outgrowth, J. Neurosci. Res. 25:443 (1990).PubMedCrossRefGoogle Scholar
  27. 27.
    K.W. Selmaj, M. Farooq, W.T. Norton, C.S. Raine and C.F. Brosnan, Proliferation of astrocytes in vitro in response to cytokines. A primary role for tumor necrosis factor, J. Immunol. 144:219 (1990).Google Scholar
  28. 28.
    M. Itoh, N. Shimomura, T. Okugawa, Y. Murata and H. Seo, Effects of interleukin 2 or 6 on DNA synthesis and expression of c-fos mRNA in Graves’ thyroid cells, Program of the 73rd Annual Meeting of The Endocrine Society, Washington, D.C., p. 340 (Abstr.) (1991).Google Scholar
  29. 29.
    T. Nabata, S. Morimoto, K. Fukuo and T. Ogihara, Biphasic effects of interleukin-2 on proliferation of cultured vascular smooth muscle cells, Jpn. J. Pharmacol. 59s2:363 (1992).Google Scholar
  30. 30.
    N. Hanley, B.C. Williams, M. Nicol, I.M. Bird and S.W. Walker, Interleukin-1b stimulates growth of adrenocortical cells in primary culture, J. Mol. Endocrinol. 8:131 (1992).PubMedCrossRefGoogle Scholar
  31. 31.
    H. Kimura, S. Yamashita, H. Namba, T. Tominaga, M. Tsuruta, N. Yokoyama, M. Izumi and S. Nagataki, Interleukin-1 inhibits human thyroid carcinoma cell growth, J. Clin. Endocrinol. Metab. 75:596 (1992).PubMedCrossRefGoogle Scholar
  32. 32.
    WA.J. Crane and R.S. Loomes, Effect of age, sex, and hormonal state on tritiated thymidine uptake by rat pituitary, Brit. J. Cancer 21:787 (1967).PubMedCrossRefGoogle Scholar
  33. 33.
    E. Carbajo-Perez, S. Carbajo, A. Orfao, J.L. Vicente-Villardon and R. Vazquez, Circadian variation in the distribution of cells throughout the different phases of the cell cycle in the anterior pituitary gland of adult male rats as analysed by flow cytometry, J. Endocrinol. 219:329 (1991).CrossRefGoogle Scholar
  34. 34.
    A. Mastro, E. Shelton and W.C. Hymer, DNA synthesis in the rat anterior pituitary. An electron microscope radioautographic study, J. Cell Biol. 43:626 (1969).PubMedCrossRefGoogle Scholar
  35. 35.
    N. Billestrup, L.W. Swanson and W. Vale, Growth hormone-releasing factor stimulates proliferation of somatotrophs in vitro, Proc. Natl. Acad. Sci. 83:6854 (1986).PubMedCrossRefGoogle Scholar
  36. 36.
    D. Tilemans, M. Andries and C. Denef, Luteinizing hormone-releasing hormone and neuropeptide Y influence deoxyribonucleic acid replication in three anterior pituitary cell types. Evidence for mediation by growth factors released from gonadotrophs, Endocrinology 130:882 (1991).CrossRefGoogle Scholar
  37. 37.
    B.W. Scheithauer, K.T. Kovacs, E.R. Laws and R.V. Randall, Pathology of invasive pituitary tumors with special reference to functional classification, J. Neurosurg. 65:733 (1986).PubMedCrossRefGoogle Scholar
  38. 38.
    A.M. Landolt, T. Shibata, P.K. Keihues and E. Tuncdogan, Growth of human pituitary adenomas: facts and speculations, Adv. Biosci. 69:53 (1988).Google Scholar
  39. 39.
    M. Buchfelder, R. Fahlbusch, E.M. Adams, M. Roth and P. Thierauf, Growth characteristics of invasive pituitary adenomas, J. Endocrinol. Invest. 14(suppl 1):33 (1991).Google Scholar
  40. 40.
    S. Ezzat and S. Melmed, The role of growth factors in the pituitary, J. Endocrinol. Invest. 13:691 (1990).PubMedGoogle Scholar
  41. 41.
    H. Houben and C. Denef, Regulatory peptides produced in the anterior pituitary, Trends Endocrinol. Metab. 1:398 (1990).PubMedCrossRefGoogle Scholar
  42. 42.
    J. Webster, J. Ham, J.S. Bevan, C.D.T. Horn and M.F. Scanlon, Preliminary characterization of growth factors secreted by human pituitary tumours, J. Clin. Endocrinol. Metab. 72:687 (1991).PubMedCrossRefGoogle Scholar
  43. 43.
    J. Halper, P.G. Parnell, B.J. Carter, P. Ren and B.W. Scheithauer, Presence of growth factors in human pituitary, Lab. Invest. 66:639 (1992).PubMedGoogle Scholar
  44. 44.
    Y. Yajima and T Saito, The effects of epidermal growth factor on cell proliferation and prolactin production by GH3 rat pituitary cells, J. Cell. Physiol. 120:249 (1984).PubMedCrossRefGoogle Scholar
  45. 45.
    J. Schwartz and R. Cherny, Intercellular communication within the anterior pituitary influencing the secretion of hypophysial hormones, Endocrine Rev. 13:453 (1992).Google Scholar
  46. 46.
    A.J. McKnight and B.J. Classon, Biochemical and immunological properties of rat recombinant interleukin-2 and interleukin-4, Immunology 75:286 (1992).PubMedGoogle Scholar
  47. 47.
    L.P. Thompson and G. DiSabato, Purification and characterization of two forms of rat interleukin-2, Cell. Immunol. 114:12 (1988).PubMedCrossRefGoogle Scholar
  48. 48.
    T. Tominaga, J. Fukata, Y. Naito, T. Usui, N. Murakami, M. Fukushima, Y. Nakai, Y. Hirai and H. Imura, Prostaglandin-dependent in vitro stimulation of adrenocortical steroidogenesis by interleukins, Endocrinology 128:526 (1991).PubMedCrossRefGoogle Scholar
  49. 49.
    Y. Naito, J. Fukata, T. Tominaga, Y. Masui, Y. Hirai, N. Murakami, S. Tamai, K. Mori and H. Imura, Adrenocorticotropic hormone-releasing activities of interleukins in a homologous in vivo system, Biochem. Biophys. Res. Commun. 164:1262 (1989).PubMedCrossRefGoogle Scholar
  50. 50.
    M.B. Sporn and A.B. Roberts, Autocrine growth factors and cancer, Nature 313:745 (1985).PubMedCrossRefGoogle Scholar
  51. 51.
    R.A. Maas, HJ. Van Weering, H.F.J. Dullens and W. Den Otter, Intratumoral low-dose interleukin-2 induces rejection of distant solid tumour, Cancer Immunol. Immunother. 33:389 (1991).PubMedCrossRefGoogle Scholar
  52. 52.
    C. Roth, L. Mir, M. Cressent, F. Quintin-Colonna, V. Ley, D. Fradelizi and P. Kourilsky, IL-2 gene transduction in malignant cells: applications in cancer containment, Bone Marrow Transplant. 9:174 (1992).PubMedGoogle Scholar
  53. 53.
    J. Bubenik, E. Lotzova, M. Indrova, J. Simova, T. Jandlova and D. Buvenikova, Use of IL-2 gene transfer in local immunotherapy of cancer, Cancer Lett. 62:257 (1992).PubMedCrossRefGoogle Scholar
  54. 54.
    S. Eccles, S. Russell and M. Collins, Inhibition of tumour growth and metastasis by IL-2 secreting rodent sarcoma cells, Program of the 4th Int. Cong, on Hormones and Cancer, Amsterdam, p. 328 (Abstr.) (1991).Google Scholar
  55. 55.
    M. Ikeda, U. Ikeda, T. Ohara, E. Kusano and S. Kano, Recombinant interleukin-6 inhibits the growth of rat mesangial cells in culture, Am. J. Pathol. 141:327 (1992).PubMedGoogle Scholar
  56. 56.
    H. Suzuki, K. Yasukawa, T. Saito, R. Goitsuka, A. Hasegawa, Y. Ohsugi, T. Taga and T. Kishimoto, Anti-human interleukin-6 receptor antibody inhibits human myeloma growth in vivo, Eur. J. Immunol. 22:1989 (1992).PubMedCrossRefGoogle Scholar
  57. 57.
    E.F. Adams, B. Rafferty and M.C. White, Interleukin 6 is secreted by breast fibroblasts and stimulates 17b-oestradiol oxidoreductase activity of MCF-7 cells: possible paracrine regulation of breast 17b-oestradiol levels, Int. J. Cancer 49:118 (1991).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • E. Arzt
    • 1
  • J. Sauer
    • 1
  • U. Renner
    • 1
  • G. K. Stalla
    • 1
  1. 1.Clinical InstituteMax-Planck-Institute of PsychiatryMunichGermany

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