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Cytokines and Sleep Mechanisms

  • James M. Krueger
  • Linda Toth
Part of the Hans Selye Symposia on Neuroendocrinology and Stress book series (HSSN, volume 3)

Abstract

The primary thesis of this essay is that infectious disease induces changes in sleep and that these sleep alterations are mediated by cytokines. More specifically, we propose that specific microbial products stimulate cytokine production and that these cytokines, in turn, induce the changes in sleep that occur during infections. Included in this scheme is the proposal that the cytokine interleukin-1 (IL1) is also involved in physiological sleep regulation.

Keywords

Sleep Deprivation Growth Hormone Release Sleep Regulation Sleep Rebound Muramyl Peptide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • James M. Krueger
    • 1
  • Linda Toth
    • 2
  1. 1.Departments of Physiology & BiophysicsUniversity of Tennessee, MemphisMemphisUSA
  2. 2.Departments of Comparative MedicineUniversity of TennesseeMemphisUSA

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