Effects of Cytokines on the Hypothalamo-Pituitary-Adrenal Axis

  • Rolf C. Gaillard
Part of the Hans Selye Symposia on Neuroendocrinology and Stress book series (HSSN, volume 3)


The interactions between the immune and endocrine systems have long been recognized, the most well-known effect being the immunosuppressive actions of glucocorticoids. More recently, however, there is growing evidence that peptide hormones have immune effects as well. Most exciting is the evidence that immune-neuroendocrine interactions or communications are bidirectional since it is now quite obvious that in addition to the recognized effects of hormones on the immune system, the latter system exerts a reciprocal effect on the endocrine system by producing substances that may profoundly affect endocrine function. In other words, it has been shown that the immune system is subject to endocrine and neural control, and that it exerts a reciprocal effect on the neuroendocrine system.


Newcastle Disease Virus Pituitary Cell Median Eminence ACTH Release Pituitary Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Rolf C. Gaillard
    • 1
  1. 1.Division of Endocrinology and Metabolism, Department of MedicineUniversity Hospital (CHUV)LausanneSwitzerland

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