Abstract
Ever since Walser (1961) demonstrated the powerful effect of sodium infusion on calcium excretion in dogs, there has been a continuing interest in the relationship between sodium and calcium excretion in human subjects and in various animal species. It has become increasingly clear that sodium intake is an important determinant of obligatory calcium loss, and this in turn has aroused interest in the role of sodium in the pathogenesis of osteoporosis and the role of salt restriction in its management. At the same time, renal physiologists have sought to describe and explain (with only partial success) the nature of the mechanisms which link sodium and calcium transport in the kidneys. The present position is that more is known about the empirical effects of sodium intake on urine calcium than on the nature of the mechanism which governs this relationship. This review is therefore necessarily more concerned with outcomes than with mechanisms, but the latter will be reviewed in brief.
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Nordin, B.E.C., Need, A.G. (1994). The Effect of Sodium on Calcium Requirement. In: Draper, H.H. (eds) Nutrition and Osteoporosis. Advances in Nutritional Research, vol 9. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9092-4_12
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DOI: https://doi.org/10.1007/978-1-4757-9092-4_12
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