Selective Depression of Peripheral Chemoreflex Loop by Sevoflurane in Lightly Anesthetized Cats
Part of the
Advances in Experimental Medicine and Biology
book series (AEMB, volume 450)
In animal studies it has been shown that volatile anesthetics depress the ventilatory response to hypoxia and hypercapnia compared to the awake state.1,2 The findings that 0.5–1% halothane reduces activity in afferent nerve fibres of the carotid bodies,3 and that halothane, enflurane and isoflurane inhibit CO2-O2 interaction1,2, indicate that these inha-lational anesthetics may directly act on the peripheral chemoreceptors. This, however, was not confirmed by Berkenbosch and coworkers,4,5 who found that in cats lightly anesthetized with chloralose-urethane, overall anesthesia with halothane, or selective administration of this agent to the peripheral chemoreceptors reduced the gains of the peripheral and central chemoreflex loops to the same extent.
KeywordsDepression Isoflurane Halothane Sevoflurane Urethane
Weiskopf, R.B., L.W. Raymond, and J.W. Severinghaus. Effects of halothane on canine respiratory responses to hypoxia with and without hypercarbia. Anesthesiology
41, 350–360, 1974.PubMedCrossRefGoogle Scholar
Hirshman, C.A., R.E. McCullough, P.J. Cohen, and J.V. Weil. Depression of hypoxic ventilatory response by halothane, enflurane and isoflurane in dogs. Br. J. Anaesth.
49, 957–963, 1977.PubMedCrossRefGoogle Scholar
Davies, R.O., M. Edwards, and S. Lahiri. Halothane depresses the response of carotid body chemoreceptors to hypoxia and hypercapnia in the cat. Anesthsiology
57, 153–159, 1982.CrossRefGoogle Scholar
van Dissel, J.T., A. Berkenbosch, C.N. Olievier, J. DeGoede, and Ph. Quanjer. Effects of halothane on the ventilatory response to hypoxia and hypercapnia in cats. Anesthesiology
62, 448–456, 1985.PubMedCrossRefGoogle Scholar
Berkenbosch, A., J. DeGoede, C.N. Olievier, and Ph. H. Quanjer. Site of action of halothane on respiratory pattern and ventilatory response to CO2
in cats. Anesthesiology
57, 389–398, 1982.PubMedCrossRefGoogle Scholar
Knill, R.L., H.T. Kieraszewicz, and B.G. Dodgson. Chemical regulation of ventilation during isoflurane sedation and anesthesia in humans. Can. Anaesth. Soc. J.
30, 607–614, 1983.PubMedCrossRefGoogle Scholar
Dahan, A., M.J.L.J. van den Elsen, A. Berkenbosch, J. DeGoede, I.C.W. Olievier, J. van Kleef, and J.G. Bovill. Effects of subanaesthetic halothane on the ventilatory response to hypercapnia and acute hypoxia in healthy volunteers. Anesthesiology
80, 727–738, 1994.PubMedCrossRefGoogle Scholar
van den Elsen, M.J.L.J., A. Dahan, A. Berkenbosch, J. DeGoede, J. van Kleef, and I. Olievier. Does subanaesthetic isoflurane affect the ventilatory response to acute isocapnic nhypoxia in healthy volunteers? Anesthesiology
81, 860–867, 1994.PubMedCrossRefGoogle Scholar
Temp, J. A., L.C. Henson, and D.S. Ward. Does a subanesthetic concentration of isoflurane blunt the ventilatory response to hypoxia? Anesthesiology
77, 1116–1124, 1992.PubMedCrossRefGoogle Scholar
DeGoede, J. A. Berkenbosch, D.S. Ward, J.W. Bellville, and C.N. Olievier. Comparison of chemoreflex gains obtained with two different methods in acts. J. Appl. Physiol.
59, 170–179, 1985.PubMedGoogle Scholar
© Springer Science+Business Media New York 1998