Do Sex-Related Differences Exist in the Respiratory Pharmacology of Opioids?
There are strong indications from human and animal studies (especially from studies using inbred strains of mice), that strain and sex-related differences exist in the analgesic potency of endogenous and exogenous administered opioids, as well as in the neurochemical and genetic mechanisms activated to modulate pain. 1–6 These differences are not restricted to the analgesic properties of opioids. Opioid-induced lethality, changes in locomotor activity, opioid addiction and opioid discrimination also exhibit sex- and/or strain-related differences.1, 3,7 Studies on strain- or sex-related differences in the influence of opioids on ventilatory control are scarce. We retrieved one study from the literature. Muraki and Kato studied the influence of morphine on the occurrence of hypothermia and respiratory rate in six strains of male mice. 8 They observed significant strain differences in these two measures of morphine action.
KeywordsLuteal Phasis Ventilatory Response Ventilatory Control Intravenous Morphine Median Preoptic Area
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- 4.Cicero, H.J., B. Nock, and E.R. Meyer. Gender-related differences in the antinociceptive properties of morphine. J. Pharmacol. Exp. Then 279: 767–773, 1996.Google Scholar
- 9.Dahan, A., E. Sarton, L. Teppema, and C. Olievier. Sex-related differences in the influence of morphine on ventilatory control in humans. Anesthesiology, in press.Google Scholar