Abstract
We are interested in characterizing the mechanical load on the respiratory system of obese pigs during wakefulness and sleep. These animals exhibit sleep-disordered breathing, manifest by characteristics similar to the human obstructive sleep apnea/hypopnea syndrome including inspiratory flow limitation (FL). During inspiratory FL, airflow becomes dissociated from the driving pressure; under these conditions, traditional measures such as resistance may not be suitable for describing mechanical load. Therefore, the purpose of this study was to mathematically describe the resistive pressure-airflow relationship during FL and non-FL inspirations. To accomplish this, two models of the resistive pressure-inspiratory airflow relationship during FL and two models for non-FL inspirations were compared for their ability to fit experimental data. The parameters of these models were then correlated with airway resistance.
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© 1998 Springer Science+Business Media New York
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Tuck, S.A., Remmers, J.E. (1998). Methods of Assessing Respiratory Impedance During Flow Limited and Non-Flow Limited Inspirations. In: Hughson, R.L., Cunningham, D.A., Duffin, J. (eds) Advances in Modeling and Control of Ventilation. Advances in Experimental Medicine and Biology, vol 450. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9077-1_20
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DOI: https://doi.org/10.1007/978-1-4757-9077-1_20
Publisher Name: Springer, Boston, MA
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