Abstract
The pontine parabrachial and Kölliker-Fuse nuclear complex (NPB-KF) has been assumed to be the anatomical location of the pneumotaxic center (11). It contains high density of respiratory neurons with various discharge patterns (3, 6). Destruction or electrical stimulation of this area is known to produce profound changes in the respiratory rhythm (5, 24, 25). It is suggested that the NPB-KF exerts its effects by specifically modulating the activity of the medullary inspiratory ‘off-switch’ mechanism, which terminates inspiration and ensures the phase transition from inspiration to expiration (8, 9). However, axonal projections from the NPB-KF to the medullary structures specifically involved in the inspiratory ‘off-switch’ effects have not been well delineated. Previous studies by us demonstrated that the nucleus raphe magnus, a structure involved in the inspiratory ‘off-switch’, received strong axonal projections from the NPB-KF area (1, 21, 22). Another possible neuron group which may transmit the function of the NPB-KF is the Bötzinger complex (Böte). The Böt. c. is known as a group of expiratory neurons in the vicinity of the retrofacial nucleus (14, 19). Most of those neurons have an augmenting firing pattern and widespread inhibitory connections to the medullary inspiratory premotor neurons (10, 12, 18). Recent studies by Smith et al. (20) and us (23) with the retrograde WGA-HRP tracing method revealed that the Böt. c. received strong projections from the lateral NPB and the KF. These studies suggest that these projections are composed of axons from the pontine respiratory and/or non-respiratory neurons which would modulate the activities of expiratory neurons in the Böt. c.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Aoki, M., Y. Fujito, Y. Kurosawa, H. Kawasaki, and I. Kosaka. Descending inputs to the upper cervical inspiratory neurons from the medullary respiratory neurons and the raphe nuclei in the cat. In: Respiratory Muscles and Their Neuromotor Control, edited by G. C. Sieck, S. C. Gandevia, and W. E. Cameron. New York: Alan R. Liss, 1987, p. 75–82.
Berman, A. L. The Brain Stem of the Cat, A Cytoarchitectonic Atlas with Stereotaxic Coordinates. University of Wisconsin Press., Madison, Wis, 1968.
Bertrand, F., A. Hugelin, and J. F. Vibert. A stereologic model of pneumotaxic oscillator based on spatial and temporal distributions of neuronal bursts. J. Neurophysiol. 37: 91–107, 1974.
Bianchi, A. L. and W. M. St. John. Medullary axonal projections of respiratory neurons of pontile pneumotaxic center. Respir. Physiol. 48: 357–373, 1982.
Cohen, M. I. Switching of the respiratory phases and evoked phrenic responses produced by rostral pontine electrical stimulation. J. Physiol. Lond. 217: 133–158, 1971.
Cohen, M. I., and S. C. Wang. Respiratory neuronal activity in pons of cat. J. Neurophysiol. 22: 33–50, 1959.
Connelly, C. A., H. H. Ellenberger, and J. L. Feldman. Respiratory activity in retrotrapezoid nucleus in cat. Am. J. Physiol. 258: L33–44, 1990.
Euler, C. von., and T. Trippenbach. Excitability changes of the inspiratory “off- switch” mechanism tested by electrical stimulation in nucleus parabrachialis in the cat. Acta. Physiol. Scand. 97: 175–188, 1976.
Euler, C. von., I. Marttila, J. E. Remmers, and T. Trippenbach. Effects of lesions in the parabrachial nucleus on the mechanisms for central and reflex termination of inspiration in the cat. Acta. Physiol. Scand. 96: 324–337, 1976.
Fedorko, L., and E. G. Merrill. Axonal projections from the rostral expiratory neurones of the Botzinger complex to medulla and spinal cord in the cat. J. Physiol. Lond. 350: 487–496, 1984.
Feldman, J. L. Neurophysiology of breathing in mammals. In: Handbook of Physiology. The Nervous System. Intrinsic Regulatory Systems of the Brain. Am. Physiol. Soc. Bethesda, MD, 1986, Sect. t, Vol. IV, pp. 463–524.
Jiang, C., and J. Lipski. Extensive monosynaptic inhibition of ventral respiratory group neurons by augmenting neurons in the Bötzinger complex in the cat. Exp. Brain. Res. 81: 639–648, 1990.
Lipski, J. Antidromic activation of neurones as an analytic tool in the study of the central nervous system. J. Neurosci. Methods. 4: 1–32, 1981.
Lipski, J. and E. G. Merrill. Electrophysiological demonstration of the projection from expiratory neurones in rostral medulla to contralateral dorsal respiratory group. Brain Res. 197: 521–524, 1980.
McAllen, R. M. and R. A. Dampney. The selectivity of descending vasomotor control by subretrofacial neurons. In: Progress in Brain Research. The Central Neural Organization of Cardiovascular Control, edited by J. Ciriello, M. M. Caverson, and C. Polosa. Amsterdam, Elsevier, Amsterdam, 1989, p. 233–242.
Mraovitch, S., M. Kumada, and D. J. Reis. Role of the nucleus parabrachialis in cardiovascular regulation in cat. Brain Res. 232: 57–75, 1982.
Merrill, E. G., and L. Fedorko. Monosynaptic inhibition of phrenic motoneurons: a long descending projection from Bötzinger neurons. J. Neurosci. 4: 2350–2353, 1984.
Merrill, E. G., J. Lipski, L. Kubin, and L. Fedorko. Origin of the expiratory inhibition of nucleus tractus solitarius inspiratory neurones. Brain Res. 263: 43–50, 1983.
Otake, K., H. Sasaki, H. Mannen, and K. Ezure. Morphology of expiratory neurons of the Bötzinger complex: an HRP study in the cat. J. Comp. Neurol. 258: 565–579, 1987.
Smith, J. C., D. E. Morrison, H. H. Ellenberger, M. R. Otto, and J. L. Feldman. Brainstem projections to the major respiratory neuron populations in the medulla of the cat. J. Comp. Neurol. 281: 69–96, 1989.
Song, G., A. Mizuguchi, and M. Aoki. Axonal projections from the pontine pneumotaxic region to the nucleus raphe magnus in cats. Respir. Physiol. 85: 329–339, 1991.
Song, G., Y. Nakazono, and M. Aoki. Differential projections to the raphe nuclei from the medial parabrachial-Kölliker-Fuse (NPBM-KF) nuclear complex and the retrofacial nucleus in cats: retrograde WGA-HRP tracing. J. Auton. Nerv. Sys. 45: 241–244, 1993.
Song, G., Y. Sato, I. Kohama, and M. Aoki. Afferent projections to the Bötzinger complex from the upper cervical cord and other respiratory related structures in the brain stem in cats: retrograde WGA-HRP tracing. J. Auton. Nerv. Sys. 56: 1–7, 1995.
St. John, W. M., R. L. Glasser, and R. A. King. Apneustic breathing after vagotomy in cats with chronic pneumotaxic center lesions. Respir. Physiol. 12: 239–250, 1971.
Tang, P. C. Localization of the pneumotaxic center in the cat. Am. J. Physiol. 172: 645–652, 1953.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1998 Springer Science+Business Media New York
About this chapter
Cite this chapter
Gang, S., Watanabe, A., Aoki, M. (1998). Axonal Projections from the Pontine Parabrachial-Kölliker-Fuse Nuclei to the Bötzinger Complex as Revealed by Antidromic Stimulation in Cats. In: Hughson, R.L., Cunningham, D.A., Duffin, J. (eds) Advances in Modeling and Control of Ventilation. Advances in Experimental Medicine and Biology, vol 450. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9077-1_13
Download citation
DOI: https://doi.org/10.1007/978-1-4757-9077-1_13
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-9079-5
Online ISBN: 978-1-4757-9077-1
eBook Packages: Springer Book Archive