Evidence for a Central Role of Protein Kinase C in Modulation of the Hypoxic Ventilatory Response in the Rat

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 450)


Protein kinase C (PKC) has been implicated as a common mechanism in the transduction of various extracellular signals into the cell (29). PKC is ubiquitous in the central nervous system and is activated by Ca2+, phospholipids and diacylglycerol (DAG) or phorbol-esters to control many physiological processes (16). The PKC family consists of three major sub-groups of isoenzymes based on their molecular structure and co-factor requirements. One sub-group comprises the classical PKC α, β1, β2, and γ isoforms, all of which share a C2 region corresponding to the Ca2+binding site (23). In the other major subgroup containing the novel PKC δ, ε, θ, η, and μ isoforms, the C2 region is absent, and activation may occur in the absence of Ca2+(14, 23, 33). Atypical isoforms such as PKC ξ, ι, and λ, also lack C2 as well as one of the repeated cysteine-rich zinc finger binding motifs within the Cl domain (24).


NMDA Receptor Ventilatory Response Nucleus Tractus Solitarii Hypoxic Ventilatory Response Intrinsic Optical Signal 
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© Springer Science+Business Media New York 1998

Authors and Affiliations

  1. 1.Constance S. Kaufman Pediatric Pulmonary Research Laboratory, Departments of Pediatrics, Physiology, and the Interdepartmental Neuroscience Training ProgramTulane University School of MedicineNew OrleansUSA

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