Fast Joule-Thomson Cryocycling Device for Cryosurgical Applications

  • B-Z. Maytal
Part of the Advances in Cryogenic Engineering book series (ACRE, volume 43)


A Linde-Hampson device has been developed, which incorporates the effects of positive and negative Joule-Thomson coefficients. Successive streams of pressurized gases, under and above their inversion temperatures (like nitrogen, argon, nitrous oxide on the one hand and neon or helium on the other), result in sequential cooling and heating. Fast cryocycling is obtained, because of the very low thermal inertia involved in a miniature Joule-Thomson “cooler”. Consequently, a fast freeze and thaw complete cycle between 325 K and 105 K was accomplished within 20 s utilizing a 5.2 mm diameter surface heat loaded probe. A computer regulated fast electromagnetic valve and a thermocouple feedback have been used to maintain any steady state intermediate temperature and control temperature extremes and periods of cooling and warmup. The fast cycling capability provides a new dimension in the domain of cryo-interaction with living tissues. In this way the cryodestructive process of undesirable cells is intensified. Cold front depth of penetration may be controlled and calibrated in an open loop through frequency dependence. This may be extremely significant for delicate surgeries like those in the eye and brain. In addition, it enables frequency dependent selective cryodestruction.


Cold Plate Liquid Cryogen Electromagnetic Valve Fast Freeze Cryogenic Engineer 
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • B-Z. Maytal
    • 1
  1. 1.Rafael InstituteHaifaIsrael

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