Residence Time Distributions in Pharmacokinetics: Behavioral and Structural Models
In contrast to other mathematical concepts used in pharmacokinetics the theory of residence time distributions (RTDs) is independent of a detailed structural model or a particular curve model. In view of the fact that interpretations of RTDs have been mostly based on compartmental models (e. g., [1, 2]), the following shortcomings of this class of structural models should be noted: 1) there is no a priori reason for the existence of homogeneous compartments. The assumption that all elementary subsystems are characterized by exponentially distributed transit times restricts the generality of the approach; 2) the definition of a sampling compartment from which elimination occurs does not allow for a differentiation between sampling upstream or downstream of the elimination site, which leads to inconsistencies in the definition of the volume of distribution, V ss .
KeywordsResidence Time Distribution Disposition Curve Inverse Gaussian Distribution Washout Curve Pharmacokinetic System
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