Fertilization in the Mouse

I. The Egg
  • Paul M. Wassarman


The mouse has been used extensively in studies of mammalian fertilization, especially during the last 20 years or so. Among the many reasons for choosing mice for such studies are (1) the tremendous wealth of knowledge available about mouse developmental and reproductive biology, (2) the relatively low cost and ease with which mice can be obtained, housed, and handled, (3) the well-established protocols available for reliably obtaining and culturing relatively large numbers of mouse gametes, (4) the well-established protocols available for carrying out fertilization with mice, both in vivo and in vitro, and (5) the firm belief that fertilization in mice is an appropriate model for understanding many aspects of human fertilization. These and other factors have made the mouse a principal player in mammalian fertilization research and, consequently, a major contributor to our understanding of the mammalian fertilization process. Several manuals are available that describe mouse husbandry and experimental manipulation of mouse gametes and embryos (Rafferty, 1970; Daniel, 1971, 1978; Hogan et al., 1986; Burki, 1986; Monk, 1987).


Zona Pellucida Acrosome Reaction Cortical Granule Meiotic Maturation Sperm Plasma Membrane 
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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Paul M. Wassarman
    • 1
  1. 1.Department of Cell and Developmental Biology, Roche Institute of Molecular BiologyRoche Research CenterNutleyUSA

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