Ornithine Transcarbamylase (OTC) in White Blood Cells and Jejunal Mucosa
The presence of OTC in white blood cells was demonstrated by Wolfe and Gatfield(1) and Snodgrass et al.(2), but was denied by Rabier et al (3). OTC deficiency was diagnosed using white blood cells by Wolfe and Gatfield (1) and Krieger et al (4). On the other hand, Snodgrass et al (2) reported that OTC deficiency in the liver can not be inferred from the measurements of the enzyme’s activity in peripheral white blood cells, because the latter parameter was normal in their patients. The presence of OTC in jejunal mucosa and reliability of this material for detecting OTC deficiency were demonstrated by Levin et al (5) and Cathelineau et al (6). However, the nature of OTC in intestinal mucosa was not clearly defined. We would like to describe some kinetic studies on OTC in white blood cells and jejunal mucosa.
KeywordsWhite Blood Cell Lymphoid Cell Urea Cycle Jejunal Mucosa Peripheral White Blood Cell
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