Guanidinosuccinic Acid and the Alternate Urea Cycle
Disturbance in nitrogen balance is the hallmark of renal insufficiency. Unlike sodium, phosphate and the myriad other minerals which the kidney regulates and balances, nitrogen cannot be reutilized by animal organisms and is restored to the environment via the urine without mechanisms for reabsorption (except for the small quantity of amino acids which are filtered and can be reutilized). Reduced filtration leads to azotemia and sets in motion a variety of hormonally regulated adaptions.
KeywordsNitrogen Balance Urea Cycle Urea Production Bilateral Nephrectomy Guanidi Noacetate
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