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Toxic Effects of Ornithine and Its Related Compounds on the Retina

  • Yujiro Ishikawa
  • Toichiro Kuwabara
  • Muriel I. Kaiser-Kupfer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 153)

Abstract

Recent studies revealed that intravitreous injection of L-ornithine causes severe damage in the pigment epithelium and photoreceptor cells of experimental animals and that the clinical and histological appearances of the damage are similar to those of gyrate atrophy, a hereditary blinding disease caused by hyper-ornithinemia due to the deficiency of ornithine-δ-aminotransferasel. In order to see cytologic toxicity, several agents which are structurally and metabolically related to ornithine were injected into the vitreous employing the technique that has been described earlier.

Keywords

Retinal Pigment Epithelium Toluidine Blue Retinal Pigment Epithelium Cell Photoreceptor Cell Amacrine Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    T. Kuwabara, Y. Ishikawa, and M.I. Kaiser-Kupfer. Experimental model of gyrate atrophy in animals. Ophthalmology (Rochester). 88: 331 (1981).Google Scholar
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    D.R. Lucas, and J.P. Newhouse, The toxic effect of sodium L-glutamate on the inner layers of the retina. Arch. Ophthalmol. 58: 193 (1957).CrossRefGoogle Scholar
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    O. Pedersen, and R.L. Karlsen, Destruction of Muller cells in the adult rat by intravitreal injection of D, L-a-aminoadipic acid. An electron microscopic study, Exp. Eye Res. 28: 569 (1979).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • Yujiro Ishikawa
    • 1
  • Toichiro Kuwabara
    • 1
  • Muriel I. Kaiser-Kupfer
    • 1
  1. 1.Laboratory of Vision Research and Clinical Branch National Eye InstituteNational Institutes of HealthBethesdaUSA

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