Abstract
A number of enzymatic defects are known such as congenital hyperammonemia, citrullinemia, argininosuccinic aciduria or hyperargininemia, which involve the urea cycle. Patients with these disorders exhibit mental retardation, presumably resulting from intoxication with ammonia. Mental retardation can be prevented by early treatment with a low protein diet and/or use of sodium benzoate to decrease the blood ammonia level.
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Goldberg, R. N., Cabal, L. A., Sinatra, F. R., Plajstek, C. E., and Hodgman, J. E., 1979, Hyperammonemia associated with perinatal asphyxia, Pediatrics, 64: 336.
Johnson, J. D., Albritton, W. L., and Sunshine, P., 1972, Hyperammonemia accompanying parenteral nutrition in newborn infants, J. Pediatr., 81: 154.
Mondzak, A., Ehrlich, G. E., and Seegmiller, J. E., 1965, An enzymatic determination of ammonia in biological fluid, J. Lab. Clin. Med., 66: 526.
Shih, V. E., 1978, Urea cycle disorders and other congenital hyperammonemic syndromes, in: “The metabolic basis of inherited diseases,” J. B. Stanbury, J. B. Wyngaarden, D. S. Fredrickson, eds., 362, New York: McGraw-Hill.
Snyderman, S. E., Sansaricq, C., Phansalkar, S. V., Schacht, R. G., and Norton, P. M., 1975, The therapy of hyperammonemia in a male neonate, Pediatrics, 56: 65.
Tada, K., Okuda, K., Watanabe, K., Limura, Y., and Yamada, S., 1979, A new method for screening for hyperammonemia, Europ. J. Pediatr., 130: 105.
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© 1982 Springer Science+Business Media New York
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Tada, K., Tateda, H., Metoki, K. (1982). A New Method for Screening of Hyperammonemia. In: Lowenthal, A., Mori, A., Marescau, B. (eds) Urea Cycle Diseases. Advances in Experimental Medicine and Biology, vol 153. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6903-6_4
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DOI: https://doi.org/10.1007/978-1-4757-6903-6_4
Publisher Name: Springer, Boston, MA
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