Sciatectomic Stimulation of Muscle Arginase and Its Implications

  • V. Mohanachari
  • P. Neeraja
  • K. Indira
  • K. S. Swami
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 153)

Abstract

Denervated muscle is characterized by high turnover of proteins, hyperammonemia, degeneration and regeneration of muscle fibers (Shahzad, 1977; Goldspink 1978; Chetty et al, 1980). In view of these conditions an enzyme like arginase, which cleaves L-arginine to L-ornithine and urea was investigated mainly because, its detoxification role in ammoniotoxemia is well established and its role in extra hepatic tissues, where other urea cycle enzymes are absent, still remains to be elucidated.

Keywords

Hydrolysis Toxicity Albumin Urea Hydroxide 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Alexander, M.D., Haslewood, E.S., Haslewood, G.A.D., Watts, D.C. and Watts, R.L., 1968, Comp. Biochem. Physiol., 26: 971–978.PubMedCrossRefGoogle Scholar
  2. Baxter, C., 1976, Abstr. Amer. Soc. Neurochet. No. 74: 100–101.Google Scholar
  3. Campbell, J.W., 1961, Arch. Biochem. Biophys., 93: 448–455.PubMedCrossRefGoogle Scholar
  4. Chetty, C.S., Naidu, R.C., and Swami, K.S., 1980, J. Biol. Sci., 2: 135–138.Google Scholar
  5. Dass, P.M.K., and Swami, K.S., 1972, Enzymologia, 42: 235–244.Google Scholar
  6. Goldspink, D.F., 1978, Comp. Biochem. Physiol., 61B: 37–41.Google Scholar
  7. Klein, E., 1960, Exptl. Cell. Res., 21: 421–429.PubMedCrossRefGoogle Scholar
  8. Lowry, O.H., Rosebrough, N.J., Farr, A.L. and Randall, R.J., 1951, J. Biol. Chem., 193: 265–275.PubMedGoogle Scholar
  9. Narayanareddy, K., and Swami, K.S., 19–75, Indian. J. Exp. Biol., 13: 343–345.Google Scholar
  10. Shahzad, M.A., 1977, J. Neurol. Sci., 33: 251–266.CrossRefGoogle Scholar
  11. Thesleff, S. and Schmidt-Nielsen, K., 1962, J. Cell. Comp. Physiol. 59: 31–34.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • V. Mohanachari
    • 1
  • P. Neeraja
    • 1
  • K. Indira
    • 1
  • K. S. Swami
    • 1
  1. 1.Department of ZoologySri Venkateswara UniversityTirupatiIndia

Personalised recommendations