Regulation of the N-Acetylglutamate Content of Rat Hepatocytes by the Glutamate Concentration

  • H. Zollner
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 153)


It is now generally accepted that the AcGlu concentration plays an important role in the regulation of urea synthesis (1–6). The mechanisms which control the AcGlu content are, however, not completely understood. AcGlu synthetase is specifically activated by arginine (7) but the mitochondrial arginine concentration is much higher than the Ka of arginine for isolated AcGlu synthetase (5). Aoyagi et al. (8) showed that the acetyl-CoA concentration affects the AcGlu content of isolated rat liver cells and Shigesada and coworkers (3) consider glutamate concentration to be an important factor in determining the AcGlu content.


Urea Cycle Pyruvate Carboxylase Glutamate Concentration Urea Synthesis Carbamyl Phosphate 


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Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • H. Zollner
    • 1
  1. 1.Institute für BiochemieUniversität GrazGrazAustria

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