Abstract
It is now generally accepted that the AcGlu concentration plays an important role in the regulation of urea synthesis (1–6). The mechanisms which control the AcGlu content are, however, not completely understood. AcGlu synthetase is specifically activated by arginine (7) but the mitochondrial arginine concentration is much higher than the Ka of arginine for isolated AcGlu synthetase (5). Aoyagi et al. (8) showed that the acetyl-CoA concentration affects the AcGlu content of isolated rat liver cells and Shigesada and coworkers (3) consider glutamate concentration to be an important factor in determining the AcGlu content.
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Zollner, H. (1982). Regulation of the N-Acetylglutamate Content of Rat Hepatocytes by the Glutamate Concentration. In: Lowenthal, A., Mori, A., Marescau, B. (eds) Urea Cycle Diseases. Advances in Experimental Medicine and Biology, vol 153. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6903-6_25
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DOI: https://doi.org/10.1007/978-1-4757-6903-6_25
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