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New Facets in Urea Cycle Disorders

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 153)

Abstract

It is a great pleasure to have so many participants at the symposium on Urea Cycle Diseases here in Okayama. Clinical, pathological and biochemical studies on metabolic disorders in the urea cycle, i.e., argininosuccinic aciduria, citrullinemia, ornithinemia, argininemia and hyperammonia have been pursued vigorously in the recent decade, and we are beginning now to at least understand some of the mechanisms of these disorders. In this symposium, additional new ideas on the origin of these diseases will be reported by many participants, and we are expecting to gather more exact information to clarify the pathogenesis. In addition to these disorders, a new clinical entity, N-acetylglutamate synthetase deficiency, will be introduced in detail by the discoverers themselves. Sparse-fur mutant mice have become a model for human ornithine transcarbamylase deficiency, and will contribute extensively to investigations of human diseases in the future.

Keywords

Urea Cycle Uremic Toxin Great Pleasure Exact Information Epileptogenic Focus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • A. Mori
    • 1
  1. 1.Department of Neurochemistry, Institute for NeurobiologyOkayama University Medical SchoolOkayama, 700Japan

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