Advertisement

Xeno-Transplantation and Xenozoonoses

  • E. Joost Ruitenberg
Chapter
Part of the Developments in Hematology and Immunology book series (DIHI, volume 37)

Abstract

Transplantation of organs such as hearts or kidneys from one individual to another has become a highly successful mode of therapy. According to reports of the FDA (US Food and Drug Administration) and CBER (Center for Biologics Evaluation and Research) in the US ten patients die every day in the US, because a needed organ is not available to them. The supply of organs in the US is based on about 5.000 donors annually. The demands, however, rose from about 20.000 in 1990 to more than 60.000 patients waiting for organs in 1998. These huge needs stimulated research on xenografts as donor organs.

Keywords

Hyperacute Rejection Marburg Virus Endogenous Type Human Kidney Cell Line Primary Peripheral Blood Mononuclear Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Michaels MG, Simmons RL. Xenotransplant-associated zoonoses.Strategies for prevention. Transplantation 1994; 57: 1–7.PubMedCrossRefGoogle Scholar
  2. 2.
    Mang R. Endogenous retroviruses and xenotransplantation. PhD thesis, University of Amsterdam 2001 (pp. 127 ).Google Scholar
  3. 3.
    Steele DJ, Auchincloss HJ. Xenotransplantation. Ann Rev Med. 1995; 46: 345–60.PubMedCrossRefGoogle Scholar
  4. 4.
    Mang R, Goudsmit J, Van der Kuyl AC. Novel endogenous type C retrovirus in baboons: complete sequence, providing evidence for baboon endogenous virus gag-pol ancestry. J Virol 1999; 73: 7021–26.PubMedGoogle Scholar
  5. 5.
    Patience C, Takeuchi Y, Weiss RA. Infection of human cells by an endogenous retrovirus of pigs. Nat Med. 1997; 3: 282–86.PubMedCrossRefGoogle Scholar
  6. 6.
    Wilson CA, Wong S, Muller J, Davidson CE, Rose TM, Burd P. Type C retrovirus released from porcine primary peripheral blood mononuclear cells infects human cells. J Virol. 1998; 72: 3082–87.PubMedGoogle Scholar
  7. 7.
    Le Tissier P, Stoye JP, Takeuchi Y, Patience C, Weiss RA. Two sets of human-tropic pig retrovirus. Nature 1997; 389: 681–82PubMedCrossRefGoogle Scholar
  8. 8.
    Van der Laan LJW, Lockey C,Griffeth BC, et al. Infection by porcine endogenous retrovirusafter islet transplantation. Nature 2000; 407: 90–94.CrossRefGoogle Scholar
  9. 9.
    Mang R, Maas J, Chen X, Goudsmit J,Van der Kuyl AC. Novel endogenous Type C retrovirus in pigs related to HERV-E: evidence for multiplication by inbreeding similar to PERV. Chapter V in reference 2.Google Scholar
  10. 10.
    Platt JL. Xenotransplantation: new risks, new gains. Nature 2000; 407: 27–30.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2002

Authors and Affiliations

  • E. Joost Ruitenberg
    • 1
    • 2
    • 3
  1. 1.CLB-SanquinAmsterdamNL
  2. 2.Department Biology and SocietyFree UniversityAmsterdamNL
  3. 3.Department of Immunology, Fac. Veterinary MedicineUniversity of UtrechtNL

Personalised recommendations