The Role of Macrophages in the Processing and Presentation of Protein Antigens to T Lymphocytes
It is clear that macrophages serve as antigen-presenting cells for a variety of specific immune responses and that many antigens are presented by macrophages to T lymphocytes in the context of the products of the I region of the major histocompatibility gene complex (MHC) of a species. For example, I-region-controlled genetic restrictions have been described for the development and expression of helper T cells (Erb and Feldmann, 1975a; Marrack and Kappler, 1978), for T-lymphocyte proliferation (Rosenthal and Shevach, 1976 Schwartz et al., 1978), and for delayed-type hypersensitivity (Miller, 1978). The use of recombinant and congenic mice and inbred guinea pigs has been an invaluable tool in establishing the role of the I region in antigen presentation. Furthermore, alloantisera to I-region gene products have demonstrated the necessity for the expression of Ia antigens on the surface of macrophages (Yamashita and Shevach, 1977; Cowing et al., 1978). The ability of multispecific anti-Ia sera to produce marked inhibition of in vitro antigen-specific T-lymphocyte proliferation to conventional and immune response (Ir) gene-controlled antigens (Shevach, 1978) indicated that a complex of Ia antigens and the nominal antigen was seen by the T lymphocyte.
KeywordsProtein Antigen Major Histocompatibility Gene Complex Nominal Antigen Detergent Extraction Pulse Exposure
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